CAJ | 학술논문

铁过载可导致骨质疏松，降低铁过载的药物有望用于防治伴有铁过载的骨质疏松症。目前临床使用的降低铁过载药物是各种铁鳌合剂，包括去铁胺、去铁酮和地拉罗司。本文总结这3种铁螯合剂临床使用特点，结合其对骨代谢影响实验研究结果，探讨铁鳌合剂作为抗骨质疏松用药的前景。
철과재가도치골질소송，강저철과재적약물유망용우방치반유철과재적골질소송증。목전림상사용적강저철과재약물시각충철오합제，포괄거철알、거철동화지랍라사。본문총결저3충철오합제림상사용특점，결합기대골대사영향실험연구결과，탐토철오합제작위항골질소송용약적전경。
Iron overload may lead to the occurrence and development of osteoporosis, and drug of decreasing i-ron overload may also have clinical potential for osteoporosis patients with iron overload.Currently, the commonly used drugs of decreasing iron are various kinds of iron chelators, which mainly include deferoxamine, deferiprone, and defera-sirox.Here is to summarize the characteristics of three iron chelators, combine with their effects on bone metabolism, and explore their clinical prospect as osteoporosis treatment.