CAJ | 학술논문

维生素D作为一种重要的类固醇激素在骨骼发育和稳态维持中发挥重要作用。机体从外界获取的维生素D需在体内经过2次羟化转变为活性1，25－二羟基维生素D3，然后与维生素D受体（ vitamin D receptor， VDR）结合后发挥生物学作用。传统观点认为1，25－二羟基维生素D3在体内主要通过内分泌途径作用于肠道和肾脏，通过调节钙磷吸收和重吸收维持矿物质稳态，并因此间接调节骨骼稳态。近年发现1，25－二羟基维生素D3能直接作用于成骨细胞、破骨细胞和软骨细胞等，通过调节其增殖、分化直接调节骨形成与骨吸收，维持骨稳态的平衡。
유생소D작위일충중요적류고순격소재골격발육화은태유지중발휘중요작용。궤체종외계획취적유생소D수재체내경과2차간화전변위활성1，25－이간기유생소D3，연후여유생소D수체（ vitamin D receptor， VDR）결합후발휘생물학작용。전통관점인위1，25－이간기유생소D3재체내주요통과내분비도경작용우장도화신장，통과조절개린흡수화중흡수유지광물질은태，병인차간접조절골격은태。근년발현1，25－이간기유생소D3능직접작용우성골세포、파골세포화연골세포등，통과조절기증식、분화직접조절골형성여골흡수，유지골은태적평형。
The important steroid hormone, vitamin D, plays an important role in the process of bone develop-ment and homeostasis.Exogenous vitamin D requires two metabolic conversions, 25-hydroxylation in the liver and 1α-hy-droxylation in the kidney, to become its active form, 1, 25-dihydroxyvitamin D, which binds to vitamin D receptor to modulate bone and mineral homeostasis.The generally accepted view is that vitamin D predominately acts on intestine and kidney to modulate calcium and phosphate homeostasis through an endocrine pathway, which indirectly regulates bone ho-meostasis.Recent years, with the advancement of tissue-specific intervention of VDR signaling pathway, scientists find a new pattern of vitamin D action which is independent of mineral metabolism.In their view, vitamin D exerts its effects mainly on the proliferation and differentiation of bone cells and then regulate bone homeostasis directly.