CAJ | 학술논문

目的：探讨乳腺癌患者化疗前后血清IGFⅠ，CA153，VEGF水平的变化及其临床意义。方法：应用放射免疫分析结合酶联法对33例乳腺癌患者进行了血清IGFⅠ，CA153，VEGF测定，并与35例正常健康人作比较。结果：乳腺癌患者在化疗前血清IGFⅠ、CA153、VEGF水平均显著地高于正常人组（P﹤0.0l），化疗后一年复发组又明显高于未复发组（P﹤0.05）。结论：检测乳腺癌患者化疗前后血清IGFⅠ，CA153，VEGF水平的变化与乳腺癌的病情和预后密切相关，具有重要的临床价值。
목적：탐토유선암환자화료전후혈청IGFⅠ，CA153，VEGF수평적변화급기림상의의。방법：응용방사면역분석결합매련법대33례유선암환자진행료혈청IGFⅠ，CA153，VEGF측정，병여35례정상건강인작비교。결과：유선암환자재화료전혈청IGFⅠ、CA153、VEGF수평균현저지고우정상인조（P﹤0.0l），화료후일년복발조우명현고우미복발조（P﹤0.05）。결론：검측유선암환자화료전후혈청IGFⅠ，CA153，VEGF수평적변화여유선암적병정화예후밀절상관，구유중요적림상개치。
Objective To investigate the patients with breast cancer before and after Chemotherapy of serum IGF I,CA153 and VEGF and their clinical significances. Method Serum CA153( with RIA),serum IGF I and VEGF( with ELISA)levels were determined in 33 patients with breast cancer both before and after chemotherapy as well as in 35 normal healthy controls. Results In patients with breast cancer before chemotherapy of serum IGF,CA153,VEGF levels were significantly higher than those in normal group(P﹤0. 0l),one year after chemotherapy recurrence group was significantly higher than non recurrent group(P﹤0. 05). Conclusion The detection of breast cancer before and after chemotherapy in patients with serum IGF I,CA153,VEGF levels are closely related to the severity and prognosis of breast cancer,they have important clinical value.