CAJ | 학술논문

放疗是恶性肿瘤的重要治疗方法，在很大程度上控制肿瘤细胞的局部浸润和提高恶性肿瘤患者总体生存率。但是肿瘤细胞自身对放射线的抗拒性往往导致放疗失败。辐射产生细胞毒性，造成DNA损伤来阻碍肿瘤细胞生长。然而，辐射也同时诱导多种促存活信号通路，如由丝氨酸－苏氨酸蛋白激酶（AKT），细胞外信号调节激酶（ERK）和共济失调毛细血管扩张症突变蛋白（ATM）介导的信号通路，导致抑制细胞凋亡，诱导细胞周期停滞和激活DNA修复系统。这些信号传导通路共同减少辐射诱导的细胞毒性，促进肿瘤细胞的辐射抵抗性。因此，针对这些促存活信号通路的研究，在肿瘤细胞的放射增敏方面将会有很大的潜力。本文就辐射诱导肿瘤细胞促存活信号通路作一综述。
방료시악성종류적중요치료방법，재흔대정도상공제종류세포적국부침윤화제고악성종류환자총체생존솔。단시종류세포자신대방사선적항거성왕왕도치방료실패。복사산생세포독성，조성DNA손상래조애종류세포생장。연이，복사야동시유도다충촉존활신호통로，여유사안산－소안산단백격매（AKT），세포외신호조절격매（ERK）화공제실조모세혈관확장증돌변단백（ATM）개도적신호통로，도치억제세포조망，유도세포주기정체화격활DNA수복계통。저사신호전도통로공동감소복사유도적세포독성，촉진종류세포적복사저항성。인차，침대저사촉존활신호통로적연구，재종류세포적방사증민방면장회유흔대적잠력。본문취복사유도종류세포촉존활신호통로작일종술。
Radiotherapy is an important treatment method for malignant tumor that to control local control infiltration of tumor cells and improve the overall survival rate of tumor patients .But the tumor cells to radiation resistance often leads to failure of radiotherapy .Radiation impede tumor cells grow th by cytotoxicity ,caused by DNA damage .However ,the radiation also induce a variety of pro-survival signaling pathways ,such as serine -threonine protein kinase (AKT) ,extracellular signal-regulated kinase (ERK) and ataxia telangiectasia mutated protein (ATM) mediated signaling pathway ,which can lead to inhibition of apoptosis ,inducing cell cycle arrest and activation of DNA repair system .These signaling pathways common to reduce radiation-induced cytotoxic-ity ,promoting radiation-resistant .Thus ,targeting these pro -survival pathways has great potential for the ra-diosensitization of cancer cells .In this paper ,the radiation-induced tumor cell pro-survival signaling pathways are review ed .