中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2015年
15期
125-126,135
,共3页
晚期肺癌%参芪扶正注射液%化疗%生活质量%毒副反应
晚期肺癌%參芪扶正註射液%化療%生活質量%毒副反應
만기폐암%삼기부정주사액%화료%생활질량%독부반응
Advanced lung cancer%Ginseng and Astragalus Fuzheng injection%Chemotherapy%Quality of life%Adverse reaction
目的：观察参芪扶正注射液联合化疗治疗肺癌的临床疗效、毒副反应及对患者生活质量的影响。方法：实验组“吉西他滨（Gem）加顺铂（DDP）”方案+参芪液250 ml(丽珠集团利民制药厂生产，批准文号，国药准字：Z199990065)，化疗第1天时使用，静脉点滴，1次/d，连用15 d，21 d为1周期，对照组单用“Gem加DDP”方案。结果：连续2个周期化疗后，实验组有效率44.1%，对照组36.4%，两组差异无显著性（P >0.05）；实验组病变进展率5.9%、对照组27.3%，差异有显著性（P＜0.05）；白细胞减低比率，实验组11.8%，对照组36.4%，差异有显著性（P<0.05）；KPS评分实验组提高55.9%，下降5.9%，对照组提高30.3%，下降27.3%，经统计学处理，差异有显著意义（x2=4.35，P<0.05）。结论：参芪扶正注射液与“GP”方案联合治疗晚期肺癌可降低化疗对患者的毒副反应，改善患者的生活质量。
目的：觀察參芪扶正註射液聯閤化療治療肺癌的臨床療效、毒副反應及對患者生活質量的影響。方法：實驗組“吉西他濱（Gem）加順鉑（DDP）”方案+參芪液250 ml(麗珠集糰利民製藥廠生產，批準文號，國藥準字：Z199990065)，化療第1天時使用，靜脈點滴，1次/d，連用15 d，21 d為1週期，對照組單用“Gem加DDP”方案。結果：連續2箇週期化療後，實驗組有效率44.1%，對照組36.4%，兩組差異無顯著性（P >0.05）；實驗組病變進展率5.9%、對照組27.3%，差異有顯著性（P＜0.05）；白細胞減低比率，實驗組11.8%，對照組36.4%，差異有顯著性（P<0.05）；KPS評分實驗組提高55.9%，下降5.9%，對照組提高30.3%，下降27.3%，經統計學處理，差異有顯著意義（x2=4.35，P<0.05）。結論：參芪扶正註射液與“GP”方案聯閤治療晚期肺癌可降低化療對患者的毒副反應，改善患者的生活質量。
목적：관찰삼기부정주사액연합화료치료폐암적림상료효、독부반응급대환자생활질량적영향。방법：실험조“길서타빈（Gem）가순박（DDP）”방안+삼기액250 ml(려주집단이민제약엄생산，비준문호，국약준자：Z199990065)，화료제1천시사용，정맥점적，1차/d，련용15 d，21 d위1주기，대조조단용“Gem가DDP”방안。결과：련속2개주기화료후，실험조유효솔44.1%，대조조36.4%，량조차이무현저성（P >0.05）；실험조병변진전솔5.9%、대조조27.3%，차이유현저성（P＜0.05）；백세포감저비솔，실험조11.8%，대조조36.4%，차이유현저성（P<0.05）；KPS평분실험조제고55.9%，하강5.9%，대조조제고30.3%，하강27.3%，경통계학처리，차이유현저의의（x2=4.35，P<0.05）。결론：삼기부정주사액여“GP”방안연합치료만기폐암가강저화료대환자적독부반응，개선환자적생활질량。
Objective: to observe the clinical efficacy, adverse reaction and influence on patients’ quality of life of Ginseng and Astragalus Fuzheng Injection combined chemotherapy in the treatment of lung cancer.Methods:the experimental group was given "gemcitabine (Gem) + cisplatin (DDP)" solution + 250 mL ginseng and astragalus injection,(produced by Lizhu group and pharmaceutical factory, approval number:Z199990065) from the first day of chemotherapy,intravenous drip,1 time a day, continued for 15 days, 21 days as 1 cycle.The control group was just given Gem + DDP.Results: for two consecutive cycles of chemotherapy, the effective rate of the experimental group was 44.1% and the control group 36.4%. There was no significant difference between the two groups (P>0.05); The lesion progress rate of the experimental group was 5.9% and the control group 27.3%.There was significant difference (P<0.05); The leukocyte reduction ratio of the experimental group was 11.8% and the control group was 36.4%.There was significant difference (P<0.05); KPS score of the experimental group increased 55.9% and the decreased 5.9%; the control group increased 30.30% and decreased 27.3%, with significant difference after statistics processing (x2= 4.35,P<0.05).Conclusion:In treating dvanced lung cancer,Ginseng and Astragalus Fuzheng Injection combined with "GP" scheme can reduce the adverse reaction of chemotherapy for patients,improve the patient's quality of life.
