CAJ | 학술논문

实验动物是医学生物学研究的重要手段，儿童是特殊的用药人群，故儿童药实验研究中选择合适的实验动物进行药理毒理学研究是保证新药研究科学性的关键问题。作者通过查阅大量文献，总结乳鼠在儿童常见疾病及其治疗药物药理学研究和毒理学评价中的应用情况，归纳乳鼠在药理毒理学研究中存在的问题，提出解决方法，为儿童药研发中受试动物的应用提供参考。
실험동물시의학생물학연구적중요수단，인동시특수적용약인군，고인동약실험연구중선택합괄적실험동물진행약리독이학연구시보증신약연구과학성적관건문제。작자통과사열대량문헌，총결유서재인동상견질병급기치료약물약이학연구화독이학평개중적응용정황，귀납유서재약리독이학연구중존재적문제，제출해결방법，위인동약연발중수시동물적응용제공삼고。
Research on laboratory animals is an important issue in biomedicine.Children are a special drug-using population.The selection of suitable experimental animals is a key issue to ensure the scientific quality of research for pediatric drugs.Based on the review of a large number of literature, the authors summarized the application of suckling mice in the pharmacological research and toxicological evaluation of pediatric drugs for the treatment of common diseases in children.We also summarized the existing problems in pediatric toxicology and proposed solutions for providing a reference of test animal application in pediatric drug research.