内蒙古医学杂志
內矇古醫學雜誌
내몽고의학잡지
INNER MONGOLIA MEDICAL JOURNAL
2015年
6期
645-648
,共4页
CA19-9%大肠癌%诊断%Meta分析
CA19-9%大腸癌%診斷%Meta分析
CA19-9%대장암%진단%Meta분석
CA1 9 -9%colorectal cancer%diagnosis%meta-analysis
目的:通过M eta分析方法评价血清CA19-9在大肠癌诊断中的临床价值。方法运用计算机和手工检索收集1989年至2012年间国内发表的关于CA19-9诊断大肠癌的文献,经严格筛选后,提取相关信息,并应用M eta-Dsic 1.4软件对入选文献的研究结果进行异质性检验进而采用相应的数学模型进行数据合并。结果纳入12篇文献(大肠癌患者组共1238人,对照组857人),CA19-9诊断大肠癌的总敏感性和特异性分别为0.36,特异度为0.89。受试者工作特征曲线下面积(AUC)为0.62。结论采用血清CA19-9诊断大肠癌的准确性较差,应结合临床表现及其它常规检验结果进行综合分析。
目的:通過M eta分析方法評價血清CA19-9在大腸癌診斷中的臨床價值。方法運用計算機和手工檢索收集1989年至2012年間國內髮錶的關于CA19-9診斷大腸癌的文獻,經嚴格篩選後,提取相關信息,併應用M eta-Dsic 1.4軟件對入選文獻的研究結果進行異質性檢驗進而採用相應的數學模型進行數據閤併。結果納入12篇文獻(大腸癌患者組共1238人,對照組857人),CA19-9診斷大腸癌的總敏感性和特異性分彆為0.36,特異度為0.89。受試者工作特徵麯線下麵積(AUC)為0.62。結論採用血清CA19-9診斷大腸癌的準確性較差,應結閤臨床錶現及其它常規檢驗結果進行綜閤分析。
목적:통과M eta분석방법평개혈청CA19-9재대장암진단중적림상개치。방법운용계산궤화수공검색수집1989년지2012년간국내발표적관우CA19-9진단대장암적문헌,경엄격사선후,제취상관신식,병응용M eta-Dsic 1.4연건대입선문헌적연구결과진행이질성검험진이채용상응적수학모형진행수거합병。결과납입12편문헌(대장암환자조공1238인,대조조857인),CA19-9진단대장암적총민감성화특이성분별위0.36,특이도위0.89。수시자공작특정곡선하면적(AUC)위0.62。결론채용혈청CA19-9진단대장암적준학성교차,응결합림상표현급기타상규검험결과진행종합분석。
Objective To evaluate the diagnostic value of carbohydrate antigen 1 9 -9 (CA1 9 -9 ) for col-orectal cancer by Meta-analysis .Methods Documents on diagnosis of colorectal cancer using CA1 9 -9 were collected through computer and manually that were published in Chinese language during 1 9 8 9 ~2 0 1 2 .After strict selection and extract information ,Meta-Dsic software was used to homogeneity test and integrated analy-sis for eligible studies .Results In total ,1 2 original studies were included (totally 1 2 3 8 subjects and 8 5 7 con-trols) .The pooled sensitivity and specificity of CA1 9 -9 for diagnosis of colorectal cancer was 0 .3 6 and 0 .8 9 re-spectively .Area Under the Curve (AUC ) of the Summary Receiver Operating Characteristics (SROC ) was 0.6 2 .Conclusion The current evidences do not recommend using CA1 9 -9 alone for the diagnosis of colorectal cancer .