医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2015年
7期
952-954
,共3页
陈娇婷%王妙飞%黄浩%罗国安
陳嬌婷%王妙飛%黃浩%囉國安
진교정%왕묘비%황호%라국안
蛇床子素%固体脂质纳米粒%熔融-匀化法%制备工艺
蛇床子素%固體脂質納米粒%鎔融-勻化法%製備工藝
사상자소%고체지질납미립%용융-균화법%제비공예
Osthol%Solid lipid nanoparticles%Melt-homogenization method%Preparation technics
目的：研究影响蛇床子素固体脂质纳米粒制备的主要因素。方法采用熔融-匀化法制备蛇床子素固体脂质纳米粒,以正交设计法筛选较理想的处方和工艺,并考察其形态、粒径及包封率。结果所制得的固体脂质纳米粒为圆形或卵圆形,粒子分散状态良好,无粘连,粒径分布范围100~200 nm,包封率59.78%。结论熔融-匀化法可用于蛇床子素固体脂质纳米粒的制备。
目的：研究影響蛇床子素固體脂質納米粒製備的主要因素。方法採用鎔融-勻化法製備蛇床子素固體脂質納米粒,以正交設計法篩選較理想的處方和工藝,併攷察其形態、粒徑及包封率。結果所製得的固體脂質納米粒為圓形或卵圓形,粒子分散狀態良好,無粘連,粒徑分佈範圍100~200 nm,包封率59.78%。結論鎔融-勻化法可用于蛇床子素固體脂質納米粒的製備。
목적：연구영향사상자소고체지질납미립제비적주요인소。방법채용용융-균화법제비사상자소고체지질납미립,이정교설계법사선교이상적처방화공예,병고찰기형태、립경급포봉솔。결과소제득적고체지질납미립위원형혹란원형,입자분산상태량호,무점련,립경분포범위100~200 nm,포봉솔59.78%。결론용융-균화법가용우사상자소고체지질납미립적제비。
Objective To study the main factors affecting the preparation of osthol ( Ost ) loaded solid lipid nanoparticies ( SLN ) . Methods The SLN were prepared by melt-homogenization method. The optimum formulation and process were selected by orthogonai design. The shape, particle size, loading capacity were investigated. Results The obtained Ost-loaded SLN were sphere or oval at a range of 100-200 nm, and were well distributed without adhesion, the loading capacity was 59. 78%. Conclusion The melt-homogenization method is available for the preparation of Ost loaded SLN.
