医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
12期
1544-1546,1556
,共4页
冠心病%血浆apelin-12超敏C反应蛋白%药物洗脱支架
冠心病%血漿apelin-12超敏C反應蛋白%藥物洗脫支架
관심병%혈장apelin-12초민C반응단백%약물세탈지가
Coronary heart disease%Apelin-12%Hypersensitive C-reactive protein%Drug-eluting stents
目的：探讨不同类型药物洗脱支架：普通药物洗脱支架（Firebird 2代，上海微创）、可降解药物涂层支架（Excel ，山东吉威）及无载体药物涂层支架（Nano ，北京乐普二代），介入治疗对血浆apelin-12及hs-CRP水平的影响。方法：收集不稳定型心绞痛（UAP）患者184例，根据植入支架不同分为Firebird 2代支架组（57例）、Excel支架组（58例）及Nano支架组（69例），另选取同期经冠脉造影证实为非冠心病患者60例为对照组；分别于术前、术后24h抽血测定血浆apelin-12及hs-CRP。结果：4组患者术前一般临床资料、3组支架组支架植入情况均无明显差异（P＞0．05）；术前3组支架组血浆apelin-12及hs-CRP水平组间比较均无明显差异；术后24h ，4组血浆apelin-12及hs-CRP较术前均有所升高（P＜0．05）；术后较术前升高幅度比较，3组支架组血浆apelin-12及hs-CRP比较无明显差异（P＞0．05），但明显高于对照组（P＜0．01）。结论：上述不同类型药物洗脱支架植入均会导致短期血浆apelin-12及hs-CRP升高；但3组间炎症因子水平均无明显差异。
目的：探討不同類型藥物洗脫支架：普通藥物洗脫支架（Firebird 2代，上海微創）、可降解藥物塗層支架（Excel ，山東吉威）及無載體藥物塗層支架（Nano ，北京樂普二代），介入治療對血漿apelin-12及hs-CRP水平的影響。方法：收集不穩定型心絞痛（UAP）患者184例，根據植入支架不同分為Firebird 2代支架組（57例）、Excel支架組（58例）及Nano支架組（69例），另選取同期經冠脈造影證實為非冠心病患者60例為對照組；分彆于術前、術後24h抽血測定血漿apelin-12及hs-CRP。結果：4組患者術前一般臨床資料、3組支架組支架植入情況均無明顯差異（P＞0．05）；術前3組支架組血漿apelin-12及hs-CRP水平組間比較均無明顯差異；術後24h ，4組血漿apelin-12及hs-CRP較術前均有所升高（P＜0．05）；術後較術前升高幅度比較，3組支架組血漿apelin-12及hs-CRP比較無明顯差異（P＞0．05），但明顯高于對照組（P＜0．01）。結論：上述不同類型藥物洗脫支架植入均會導緻短期血漿apelin-12及hs-CRP升高；但3組間炎癥因子水平均無明顯差異。
목적：탐토불동류형약물세탈지가：보통약물세탈지가（Firebird 2대，상해미창）、가강해약물도층지가（Excel ，산동길위）급무재체약물도층지가（Nano ，북경악보이대），개입치료대혈장apelin-12급hs-CRP수평적영향。방법：수집불은정형심교통（UAP）환자184례，근거식입지가불동분위Firebird 2대지가조（57례）、Excel지가조（58례）급Nano지가조（69례），령선취동기경관맥조영증실위비관심병환자60례위대조조；분별우술전、술후24h추혈측정혈장apelin-12급hs-CRP。결과：4조환자술전일반림상자료、3조지가조지가식입정황균무명현차이（P＞0．05）；술전3조지가조혈장apelin-12급hs-CRP수평조간비교균무명현차이；술후24h ，4조혈장apelin-12급hs-CRP교술전균유소승고（P＜0．05）；술후교술전승고폭도비교，3조지가조혈장apelin-12급hs-CRP비교무명현차이（P＞0．05），단명현고우대조조（P＜0．01）。결론：상술불동류형약물세탈지가식입균회도치단기혈장apelin-12급hs-CRP승고；단3조간염증인자수평균무명현차이。
Objective:To explore the influence of different types of rapamycin drug-eluting stents rapamycin drug-elu-ting stent(Firebird 2 generation ,shanghai) ,Biodegradable rapamycin drug-eluting stents (Excel ,jiwei shandong )and polymer-free rapamycin drug-eluting stent(Nano ,lepu beijing)on serum apelin-12 and hypersensitive C-reactive protein (hs-CRP) levels after stents implation .Methods:Consecutive 184 patients with unstable angina pectoris (UAP)by angi-ography were divided into Firebird 2 generation group (57 cases) ,Excel group (58 cases) and Nano group (69 cases) , the patients undergoing coronary angiography without coronary heart disease(CHD) as control group during the same period;the serum concentration of apelin-12 and hs-CRP were determined before and at 24h after coronary intervention . Results:The clinical data in four groups and angiography characteristics in three stent groups had no significant differ-ences (P>0 .05);the serum concentration of apelin-12 and hs-CRP in the three stent groups have no significant differ-ence before coronary intervention (P>0 .05);the serum apelin-12 and hs-CRP levels at 24h after coronary intervention were significantly higher in each group than baseline(P<0 .05);compared with pre-operation and at 24h after coronary intervention ,the increased rate of serum apelin-12 and hs-CRP levels in the three stent groups were significantly higher (P<0 .01)than the control group but with no significant difference(P>0 .05) .Conclusion:Different types of rapamycin drug-eluting stents will lead rising of levels of serum apelin-12 and hs-CRP after stent implation;but the inflammatory factor levels had no obvious differences between the three groups .
