中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2015年
18期
142-144
,共3页
手足综合征%超声药物透入疗法%卡培他滨
手足綜閤徵%超聲藥物透入療法%卡培他濱
수족종합정%초성약물투입요법%잡배타빈
Hand-foot syndrome%Ultrasound therapy drug penetration%Capecitabine
目的：观察超声药物透入疗法预防及治疗卡培他滨所致手足综合征（hand foot s yndrom e , H FS）的疗效。方法：选取卡培他滨化疗患者共35例，35例均为经病理学或细胞学确诊的乳腺癌、结肠癌、胃癌患者。随机分为试验组18例和对照组17例。卡培他滨每日量为2500 mg/m2，分2次口服，连用14 d，休息7 d，21 d为1个周期。预防组18例，化疗同时运用超声药物透入仪导入维生素B6注射液，隔日1次。对照组17例，化疗同时给予维生素B6口服至化疗结束。结果：试验组18例患者中3例发生Ⅰ级手足综合征，发生率为16.7%，对照组手足综合征发生率为44.4%，两者有显著性差异（P<0.05）。结论：超声药物透入疗法可有效防治卡培他滨化疗所致手足综合征。
目的：觀察超聲藥物透入療法預防及治療卡培他濱所緻手足綜閤徵（hand foot s yndrom e , H FS）的療效。方法：選取卡培他濱化療患者共35例，35例均為經病理學或細胞學確診的乳腺癌、結腸癌、胃癌患者。隨機分為試驗組18例和對照組17例。卡培他濱每日量為2500 mg/m2，分2次口服，連用14 d，休息7 d，21 d為1箇週期。預防組18例，化療同時運用超聲藥物透入儀導入維生素B6註射液，隔日1次。對照組17例，化療同時給予維生素B6口服至化療結束。結果：試驗組18例患者中3例髮生Ⅰ級手足綜閤徵，髮生率為16.7%，對照組手足綜閤徵髮生率為44.4%，兩者有顯著性差異（P<0.05）。結論：超聲藥物透入療法可有效防治卡培他濱化療所緻手足綜閤徵。
목적：관찰초성약물투입요법예방급치료잡배타빈소치수족종합정（hand foot s yndrom e , H FS）적료효。방법：선취잡배타빈화료환자공35례，35례균위경병이학혹세포학학진적유선암、결장암、위암환자。수궤분위시험조18례화대조조17례。잡배타빈매일량위2500 mg/m2，분2차구복，련용14 d，휴식7 d，21 d위1개주기。예방조18례，화료동시운용초성약물투입의도입유생소B6주사액，격일1차。대조조17례，화료동시급여유생소B6구복지화료결속。결과：시험조18례환자중3례발생Ⅰ급수족종합정，발생솔위16.7%，대조조수족종합정발생솔위44.4%，량자유현저성차이（P<0.05）。결론：초성약물투입요법가유효방치잡배타빈화료소치수족종합정。
Objective:To investigate the effects of prevention and treatmentof ultrasound therapy drug penetration on capecitabine induced hand-footsyndrome (hand footsyndrome e, HFS) [1] . Methods:35 cases with capecitabine chemotherapy confirmed by pathology or cytology of breastcancer, colon cancer, stomach cancer were selected and randomly divided into an experimental group with 18 cases and a control group with 17 cases. The amountof capecitabine was 2500 mg/m2, twice orally, 14 days continuously, rest7 days, 21 days for a p eriod.18 pa tients in the prevention group were treated with ultrasound dru g pe netration i nstrumenti mported vi tamin B6 i njection, every other day, while 17 cases in the control group were treated with vitamin B6 oral chemotherapy until the end of chemotherapy. Results:3 cases among 18 patients in the experimental group occurredⅠgrade hand-footsyndrome, the rate was 16.7%, while thatin the control group hand-footsyndrome was 44.4%with significantdifference (P<0.05).Conclusion:Ultrasound drug penetration therapy can effectively control capecitabine chemotherapy induced hand-footsyndrome.
