中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
17期
126-128
,共3页
门冬胰岛素%妊娠期糖尿病%可行性%安全性
門鼕胰島素%妊娠期糖尿病%可行性%安全性
문동이도소%임신기당뇨병%가행성%안전성
Insulin aspart%Gestational diabetes mellitus%Feasibility%Safety
目的：评价门冬胰岛素治疗妊娠期糖尿病(GDM)的可行性及安全性。方法选取2011年10月~2014年10月本院收治的80例GDM患者，随机分为观察组和对照组，每组40例。观察组采用门冬胰岛素治疗，对照组采用生物合成人胰岛素治疗。观察并比较两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)及血浆糖化血红蛋白(HbA1c)水平，同时记录两组并发症的发生情况。结果治疗前，两组的FPG、2 h PG及HbA1c水平比较，差异无统计学意义(P>0.05)；治疗后，两组较治疗前的各指标均有改善，与治疗前差异有统计学意义(P<0.05)，且治疗后观察组与对照组比较，差异有统计学意义(P<0.05)；观察组的并发症总发生率为12.5%，对照组为32.5%，两组差异有统计学意义(χ2=5.8039，P=0.0160)。结论采用门冬胰岛素治疗GDM可显著改善患者的临床症状，降低并发症发生率，安全有效，值得临床推广。
目的：評價門鼕胰島素治療妊娠期糖尿病(GDM)的可行性及安全性。方法選取2011年10月~2014年10月本院收治的80例GDM患者，隨機分為觀察組和對照組，每組40例。觀察組採用門鼕胰島素治療，對照組採用生物閤成人胰島素治療。觀察併比較兩組治療前後空腹血糖(FPG)、餐後2 h血糖(2 h PG)及血漿糖化血紅蛋白(HbA1c)水平，同時記錄兩組併髮癥的髮生情況。結果治療前，兩組的FPG、2 h PG及HbA1c水平比較，差異無統計學意義(P>0.05)；治療後，兩組較治療前的各指標均有改善，與治療前差異有統計學意義(P<0.05)，且治療後觀察組與對照組比較，差異有統計學意義(P<0.05)；觀察組的併髮癥總髮生率為12.5%，對照組為32.5%，兩組差異有統計學意義(χ2=5.8039，P=0.0160)。結論採用門鼕胰島素治療GDM可顯著改善患者的臨床癥狀，降低併髮癥髮生率，安全有效，值得臨床推廣。
목적：평개문동이도소치료임신기당뇨병(GDM)적가행성급안전성。방법선취2011년10월~2014년10월본원수치적80례GDM환자，수궤분위관찰조화대조조，매조40례。관찰조채용문동이도소치료，대조조채용생물합성인이도소치료。관찰병비교량조치료전후공복혈당(FPG)、찬후2 h혈당(2 h PG)급혈장당화혈홍단백(HbA1c)수평，동시기록량조병발증적발생정황。결과치료전，량조적FPG、2 h PG급HbA1c수평비교，차이무통계학의의(P>0.05)；치료후，량조교치료전적각지표균유개선，여치료전차이유통계학의의(P<0.05)，차치료후관찰조여대조조비교，차이유통계학의의(P<0.05)；관찰조적병발증총발생솔위12.5%，대조조위32.5%，량조차이유통계학의의(χ2=5.8039，P=0.0160)。결론채용문동이도소치료GDM가현저개선환자적림상증상，강저병발증발생솔，안전유효，치득림상추엄。
Objective To evaluate the feasibility and safety of insulin aspart in the treatment of gestational diabetes mellitus(GDM). Methods 80 patients with GDM admitted into our hospital from October 2011 to October 2014 were se-lected and evenly divided into observation group and control group in random.Observation group was used insulin as-part,while control group was adopted biosynthetic human insulin.Fasting plasma glucose(FPG),2 hours plasma glucose(2 h PG),and the level of glycosylated hemoglobin (HbA1c) between two groups was observed and compared.At the same time,the occurrence of complications between two groups was recorded. Results Before treatment,FPG,2 h PG and HbAlc in two groups was compared,the difference was no significant (P>0.05).After treatment,indexes in two groups was improved compared with prior treatment,the difference was significant(P<0.05).Differences in observation group had sta-tistical significances after treatment in comparison with those in control group (P<0.05).The total incidence of complica-tions in observation group was 12.5%,while the control group was 32.5%,the difference was significant (χ2=5.8039,P=0.0160). Conclusion Application of insulin aspart to treat GDM can significantly improve patient’s clinical symptoms, reduce the incidence of complications,which is safe and effective,it is worthy of clinical promotion.
