CAJ | 학술논문

目的：探讨胸腺五肽联合抗组胺药治疗慢性荨麻疹（CU）的效果。方法：根据患者自愿，将150例患者分为观察组（95例）和对照组（55例）。两组在抗组胺药治疗的基础上，对照组隔日注射胸腺五肽2 mg，观察组每日注射胸腺五肽10 mg。比较两组疗效、不良反应发生率和复发率。结果：观察组治疗有效率为93.7%，显著高于对照组（x2=11.716，P<0.05）。观察不良反应发生率为7.4%，与对照组无统计学差异（x2=0.907，P>0.05）。观察组复发率为17.4%，显著低于对照组（x2=8.454，P<0.05）。结论：在抗组胺药的基础上，每日持续使用胸腺五肽治疗慢性荨麻疹可以获得更好的疗效，降低复发率，值得临床推广运用。
목적：탐토흉선오태연합항조알약치료만성담마진（CU）적효과。방법：근거환자자원，장150례환자분위관찰조（95례）화대조조（55례）。량조재항조알약치료적기출상，대조조격일주사흉선오태2 mg，관찰조매일주사흉선오태10 mg。비교량조료효、불량반응발생솔화복발솔。결과：관찰조치료유효솔위93.7%，현저고우대조조（x2=11.716，P<0.05）。관찰불량반응발생솔위7.4%，여대조조무통계학차이（x2=0.907，P>0.05）。관찰조복발솔위17.4%，현저저우대조조（x2=8.454，P<0.05）。결론：재항조알약적기출상，매일지속사용흉선오태치료만성담마진가이획득경호적료효，강저복발솔，치득림상추엄운용。
Objective:To investigate efficacy of thymopoietin-5 plus antihistamines on chronic urticaria.Methods:150 patients were divided into obs ervation group ( 95 c ases) a nd control group (55 cases).With antihistamines in both groups;the c ontrol group w as injected 2mg thymopoietin-5 e very 2 days while the obs ervation group w as injected 10mg thymopoietin-5 every da y.Results:The e fficacy in the observation group was 93.7%,significantly higher than thatin control group(x2=11.716,P<0.05).The adverse reaction rate in the observation was 7. 4%,with no s ignificantdi fference ( x2=0.907, P>0.05). The re currence rate of obs ervation group w as 17. 39%, significantly l ower (x2=8.454, P<0.05). Conclusion:With antihistamine before, continuous application of thymopoietin-5 can obtain better efficacy for chronic urticaria and less adverse reaction, which is worthy of clinical promotion.