国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2015年
3期
169-172
,共4页
李雪%罗玉辉%陈体辉%李卫民
李雪%囉玉輝%陳體輝%李衛民
리설%라옥휘%진체휘%리위민
复发性生殖器疱疹%匹多莫德片%细胞免疫功能%复发率
複髮性生殖器皰疹%匹多莫德片%細胞免疫功能%複髮率
복발성생식기포진%필다막덕편%세포면역공능%복발솔
Recurrent genital herpes%Pidotimod tablet%Cellular immune function%Recurrence rate
目的 探讨匹多莫德片治疗复发性生殖器疱疹的疗效分析.方法 将复发性生殖器疱疹患者122例按照1∶1的比例随机分成对照组和观察组,每组各61例.对照组应用盐酸伐昔洛韦片治疗.观察组在对照组治疗的基础上联合匹多莫德片治疗.结果 观察组总有效率为93.4％,对照组的总有效率为80.32％,其差异有统计学意义(P＜0.05).观察组患者的症状消失、结痂、止疱、皮损愈合时间短于对照组患者的症状消失、结痂、止疱、皮损愈合时间,其差异显著(P＜0.01).治疗后,观察组患者的CD3+、CD4+、CD4 +/CD8+水平高于对照组患者的CD3+、CD4+、CD4 +/CD8+,且观察组CD8+水平则低于对照组患者的CD8+水平,差异显著(P＜0.01).随访6个月和12个月显示,观察组复发率为24.59％、44.26％少于对照组的42.62％、70.49％,差异有统计学意义(P＜0.05).结论 匹多莫德片治疗复发性生殖器疱疹疗效确切,能够有效调节患者的细胞免疫,提高患者的免疫抵抗力,降低患者的复发率.
目的 探討匹多莫德片治療複髮性生殖器皰疹的療效分析.方法 將複髮性生殖器皰疹患者122例按照1∶1的比例隨機分成對照組和觀察組,每組各61例.對照組應用鹽痠伐昔洛韋片治療.觀察組在對照組治療的基礎上聯閤匹多莫德片治療.結果 觀察組總有效率為93.4％,對照組的總有效率為80.32％,其差異有統計學意義(P＜0.05).觀察組患者的癥狀消失、結痂、止皰、皮損愈閤時間短于對照組患者的癥狀消失、結痂、止皰、皮損愈閤時間,其差異顯著(P＜0.01).治療後,觀察組患者的CD3+、CD4+、CD4 +/CD8+水平高于對照組患者的CD3+、CD4+、CD4 +/CD8+,且觀察組CD8+水平則低于對照組患者的CD8+水平,差異顯著(P＜0.01).隨訪6箇月和12箇月顯示,觀察組複髮率為24.59％、44.26％少于對照組的42.62％、70.49％,差異有統計學意義(P＜0.05).結論 匹多莫德片治療複髮性生殖器皰疹療效確切,能夠有效調節患者的細胞免疫,提高患者的免疫牴抗力,降低患者的複髮率.
목적 탐토필다막덕편치료복발성생식기포진적료효분석.방법 장복발성생식기포진환자122례안조1∶1적비례수궤분성대조조화관찰조,매조각61례.대조조응용염산벌석락위편치료.관찰조재대조조치료적기출상연합필다막덕편치료.결과 관찰조총유효솔위93.4％,대조조적총유효솔위80.32％,기차이유통계학의의(P＜0.05).관찰조환자적증상소실、결가、지포、피손유합시간단우대조조환자적증상소실、결가、지포、피손유합시간,기차이현저(P＜0.01).치료후,관찰조환자적CD3+、CD4+、CD4 +/CD8+수평고우대조조환자적CD3+、CD4+、CD4 +/CD8+,차관찰조CD8+수평칙저우대조조환자적CD8+수평,차이현저(P＜0.01).수방6개월화12개월현시,관찰조복발솔위24.59％、44.26％소우대조조적42.62％、70.49％,차이유통계학의의(P＜0.05).결론 필다막덕편치료복발성생식기포진료효학절,능구유효조절환자적세포면역,제고환자적면역저항력,강저환자적복발솔.
Objective To study the therapeutic effect of Pidotimod tablets in the treatment of recurrent genital herpes.Methods 122 patients with recurrent genital herpes,were randomly divided into the control group and the observation group according to 1∶ 1,61 cases in each.The control group was treated with valacyclovir hydrochloride tablets and the observation group was treated with Pidotimod tablet on the base of therapeutic schemes of the control group.Results The total effective rate of the observation group was 93.44％and 80.32％ in the control group.The difference was significant (P ＜ 0.05).Symptoms disappear,crusting,blisters,lesions healing time of the observation group were shorter than those of the control group and the difference was significant (P ＜0.01).After treatment,CD3 + 、CD4 + 、CD4 +/CD8 + level of the observation group were higher than those of the control group,while CD8 + level in the observation group patients were lower than that of in the control group,the difference was significant (P ＜0.01).6 and 12 months of followup,the recurrence rate of the observation group were 24.59％ and 44.26％,42.62％ and 70.49％ in the control group.The difference was significant (P ＜ 0.05).Conclusions It is has good clinical effect for Pidotirnod tablets to cure genital herpes with definite curative effect,effectively regulating the cell immune of patients,improving the patient's immune resistance and reducing the relapse rate.
