CAJ | 학술논문

目的：探讨宫颈癌术后应用调强放疗同期化疗的临床效果。方法选取2010年11月~2011年11月本院收治的宫颈癌患者93例，将其根据治疗方法分为对照组(40例)与治疗组(53例)。对照组实施常规放疗+TP化疗方案，治疗组实施调强放疗+TP化疗方案。比较两组1、3年内的肿瘤局部控制情况、生存率及不良反应情况。结果治疗组术后1、3年局部控制率与对照组差异无统计学意义(P>0.05)；治疗组术后1、3年生存率与对照组差异无统计学意义(P>0.05)。两组的不良反应(骨髓抑制、放射性直肠炎及膀胱炎)发生情况比较，差异有统计学意义(P<0.05)。结论宫颈癌术后应用调强放疗同期化疗可有效提高肿瘤局部控制率，减少不良反应，对延长患者的生存期有明显作用，值得推广应用。
목적：탐토궁경암술후응용조강방료동기화료적림상효과。방법선취2010년11월~2011년11월본원수치적궁경암환자93례，장기근거치료방법분위대조조(40례)여치료조(53례)。대조조실시상규방료+TP화료방안，치료조실시조강방료+TP화료방안。비교량조1、3년내적종류국부공제정황、생존솔급불량반응정황。결과치료조술후1、3년국부공제솔여대조조차이무통계학의의(P>0.05)；치료조술후1、3년생존솔여대조조차이무통계학의의(P>0.05)。량조적불량반응(골수억제、방사성직장염급방광염)발생정황비교，차이유통계학의의(P<0.05)。결론궁경암술후응용조강방료동기화료가유효제고종류국부공제솔，감소불량반응，대연장환자적생존기유명현작용，치득추엄응용。
Objective To study the clinical effect of intensive-modulated radiotherapy with concurrent chemotherapy after cervical cancer operation. Methods From November 2010 to November 2011,93 patients with cervical cancer treated in our hospital were selected and they were divided into control group (40 cases) and treatment group (53 cases) according to treatment method.Control group was given routine radiotherapy combined with TP chemotherapy scheme, while treatment group was given intensive-modulated radiotherapy combined with TP chemotherapy scheme.Local con-trol of tumor,survival rate and adverse reaction within 1 year,3 years was compared respectively. Results There was no statistical difference of the local control rate after 1 year and 3 years operation between two groups (P>0.05); there was no statistical difference of the survival rate after 1 year and 3 years operation between two groups (P>0.05);there was a statistical difference of incidence of adverse reaction (bone marrow inhibition,radiation proctitis and cystitis) between two groups (P<0.05). Conclusion Intensive-modulated radiotherapy with concurrent chemotherapy applied after cervical cancer operation can effectively improve local control rate of tumor,reduce adverse reaction,has obvious role for prolong-ing the survival period of patients,it is worthy of clinical promotion and application.