CAJ | 학술논문

目的：探讨手术去势对前列腺癌患者血脂代谢的影响。方法：选择45例行双侧睾丸切除术前列腺癌患者，检测睾酮（T）、游离睾酮（FT）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（APO-A1）、载脂蛋白B（APO-B）。结果：患者术后睾酮、游离睾酮的水平均低于术前，且术后1、3、6个月、1年呈逐渐下降趋势，差异有统计学意义（P<0.05）；TG术后3个月的水平均高于术前，TC、HDL-C术后水平均高于术前，LDL-C的水平均低于术前，手术前后比较差异均有统计学意义（P<0.05）。APO-A1、APO-B治疗前后差异无统计学意义（P>0.05）。结论：前列腺癌患者手术去势后，随着雄性激素的降低，血脂代谢可出现异常变化。
목적：탐토수술거세대전렬선암환자혈지대사적영향。방법：선택45례행쌍측고환절제술전렬선암환자，검측고동（T）、유리고동（FT）、감유삼지（TG）、총담고순（TC）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、재지단백A1（APO-A1）、재지단백B（APO-B）。결과：환자술후고동、유리고동적수평균저우술전，차술후1、3、6개월、1년정축점하강추세，차이유통계학의의（P<0.05）；TG술후3개월적수평균고우술전，TC、HDL-C술후수평균고우술전，LDL-C적수평균저우술전，수술전후비교차이균유통계학의의（P<0.05）。APO-A1、APO-B치료전후차이무통계학의의（P>0.05）。결론：전렬선암환자수술거세후，수착웅성격소적강저，혈지대사가출현이상변화。
Objective:To analyze the effect of surgical castration on lipid metabolism in patients with prostate cancer. Method:45 patients with advanced prostate cancer had undergone the bilateral orchiectomy.The serum levels of T,FT,TG, TC,HDL-C,LDL-C,APO-A1,APO-B were determined before and after castration.Result:T and FT after castration were significantly lower than that before castration,and showed a gradual decrease from 1 month to 1 year,the differences were statistically significant(P<0.05);after castration,TG increased significantly 3 months after castration,TC and HDL-C increased significantly after castration,LDL-C decreased significantly after castration,the differences were statistically significant(P<0.05).APO-A1 and APO-B were not changed,the difference was no statistically significant(P<0.05). Conclusion:After surgical castration,the androgen levels decrease,and the lipid metabolism becomes abnormal.