中国执业药师
中國執業藥師
중국집업약사
CHINA LICENSED PHARMACIST
2015年
7期
31-37
,共7页
质子泵抑制剂%超适应证%应用风险%药学监护
質子泵抑製劑%超適應證%應用風險%藥學鑑護
질자빙억제제%초괄응증%응용풍험%약학감호
Proton Pump Inhibitors%Overindication%Application Risk%Pharmaceutical Care
质子泵抑制剂的问市拓展了抑酸药的作用途径，其对H+-K+-ATP酶有高度选择性，抑制胃酸形成的最后步骤，对基础胃酸、各种应激性胃酸分泌或出血，均产生有效的抑制作用。本文借助近4年国内医院临床应用数据，查阅近年来国内、外相关文献，进行归纳和分析，总结其国内应用趋势与应用中的风险，以及临床应用中的监护要点。应加强对质子泵抑制剂应用的监管，制订《临床应用指导原则》，权衡患者获益大于可能出现的风险，促进质子泵抑制剂的合理应用。
質子泵抑製劑的問市拓展瞭抑痠藥的作用途徑，其對H+-K+-ATP酶有高度選擇性，抑製胃痠形成的最後步驟，對基礎胃痠、各種應激性胃痠分泌或齣血，均產生有效的抑製作用。本文藉助近4年國內醫院臨床應用數據，查閱近年來國內、外相關文獻，進行歸納和分析，總結其國內應用趨勢與應用中的風險，以及臨床應用中的鑑護要點。應加彊對質子泵抑製劑應用的鑑管，製訂《臨床應用指導原則》，權衡患者穫益大于可能齣現的風險，促進質子泵抑製劑的閤理應用。
질자빙억제제적문시탁전료억산약적작용도경，기대H+-K+-ATP매유고도선택성，억제위산형성적최후보취，대기출위산、각충응격성위산분비혹출혈，균산생유효적억제작용。본문차조근4년국내의원림상응용수거，사열근년래국내、외상관문헌，진행귀납화분석，총결기국내응용추세여응용중적풍험，이급림상응용중적감호요점。응가강대질자빙억제제응용적감관，제정《림상응용지도원칙》，권형환자획익대우가능출현적풍험，촉진질자빙억제제적합리응용。
The development and use of proton pump inhibitors have expanded the functional mechanism of acid-inhibitory drugs. Proton pump inhibitor is highly selective to H+-K+-ATP enzyme,it can suppress the formation of gastric acid in the last step and has the inhibitory effects on basic gastric acid and stress gastric acid secretion or haemorrhage. This paper summarized the data of clinical application in hospitals in the recent four years through domestic and foreign literature review. The trend and risks of the application of proton pump inhibitors were analyzed,and the critical points in monitoring of clinical application were put forward. It was suggested that the supervision of the use of proton pump inhibitors should be strengthened,theGuidingPrinciplesforClinical ApplicationofProtonPumpInhibitorsshould be worked out and the benefit and possible risks in patients’ application should be balanced so as to promote the rational use of proton pump inhibitors.
