CAJ | 학술논문

目的：探讨单纯运用Q开关1064nm激光与联合口服氨甲环酸片治疗黄褐斑的疗效及安全性。方法：将36例确诊为黄褐斑的患者随机平均分为A、B两组。A组：采用Q开关1064nm Nd：YAG激光联合口服氨甲环酸片治疗；B组：单纯激光治疗。激光治疗间隔为4周，共8次，光斑直径6mm，能量密度3.0～3.5J/cm2，脉冲频率10Hz；氨甲环酸片每日2次，每次250mg，连续口服6个月。治疗过程中记录不良反应，由两位医师对每次治疗前及疗程结束后1个月照片进行mMASI评分，同时患者接受满意度调查，并进行相关统计学分析。结果：A、B两组间治疗前后的mMASI评分下降率有统计学差异(P＜0.05)，A组患者平均起效时间为2.47个月，B组为4.69个月；A组患者满意率72.22%，B组患者满意率61.11%，两组间满意率比较有统计学差异(P＜0.05)。所有激光治疗患者未见严重不良反应，口服氨甲环酸片的患者中有1例胃肠道反应，1例患者自觉月经量减少。结论：口服氨甲环酸片联合Q开关1064nm激光治疗黄褐斑与单纯激光治疗相比，具有起效快、疗效高等优点。
목적：탐토단순운용Q개관1064nm격광여연합구복안갑배산편치료황갈반적료효급안전성。방법：장36례학진위황갈반적환자수궤평균분위A、B량조。A조：채용Q개관1064nm Nd：YAG격광연합구복안갑배산편치료；B조：단순격광치료。격광치료간격위4주，공8차，광반직경6mm，능량밀도3.0～3.5J/cm2，맥충빈솔10Hz；안갑배산편매일2차，매차250mg，련속구복6개월。치료과정중기록불량반응，유량위의사대매차치료전급료정결속후1개월조편진행mMASI평분，동시환자접수만의도조사，병진행상관통계학분석。결과：A、B량조간치료전후적mMASI평분하강솔유통계학차이(P＜0.05)，A조환자평균기효시간위2.47개월，B조위4.69개월；A조환자만의솔72.22%，B조환자만의솔61.11%，량조간만의솔비교유통계학차이(P＜0.05)。소유격광치료환자미견엄중불량반응，구복안갑배산편적환자중유1례위장도반응，1례환자자각월경량감소。결론：구복안갑배산편연합Q개관1064nm격광치료황갈반여단순격광치료상비，구유기효쾌、료효고등우점。
Objective To compare the clinical efficacy and safety of using Medlite C6 Q-switch Nd:YAG Iaser and combined with tranexamic acid for the treatment of melasma. Method 36 female patients with melasma were divided into two groups,A and B,n=18.Group A were given Q-switch Nd:YAG 1 064nm laser every 4 weeks for 8 times,6mm spot,3.0-3.5J/cm2 energy,combined with oral tranexamic acid tablets for 6 month,500mg/day,twice a day.While group B were only treated with laser. The side effects were recorded and therapeutic efficacy were assessed by mMASI score and patient satisfaction rates. Result Both groups had achieved significant decrease from base line in mMASI score.Satisfaction rate of group A was 72.22%,while in group B it was 61.11%,there were statistically significant between the two groups(P<0.05).No severe adverse reactions were seen,exclude gastrointestinal reaction had happened on one patient,and another one complain of menstrual quantity decreases in group B. Conclusion Compare with laser-alone group,combination therapy can promote the efficacy of melasma and without severe side-effects.