CAJ | 학술논문

目的：探讨右佐匹克隆治疗慢性紧张型头痛的临床疗效及心理干预对用药依从性的影响。方法将118例慢性紧张型头痛患者随机分为对照组和观察组，各59例。对照组予以萘普生治疗，观察组加用右佐匹克隆，均进行针对性心理干预，疗程均为8周。结果与对照组相比，观察组治疗总有效率显著提高（ P﹤0.05）；两组患者治疗后疼痛视觉模拟评分（VAS）。较治疗前均有明显下降，观察组患者自第4周起即较对照组下降显著（ P﹤0.05）；在疼痛发作持续次数评分方面，观察组自第4周开始评分较治疗前即有明显下降，而对照组在第6周时才出现显著下降，组间有显著性差异（ P﹤0.05）；在疼痛持续时间评分方面，观察组患者在第2周时出现明显下降，对照组则在第4周时出现明显下降，组间差异显著（ P﹤0.05）；两组患者服药依从率及药品不良反应发生率间未见明显差异（ P﹥0.05）。结论右佐匹克隆治疗慢性紧张型头痛安全、有效，同时予针对性心理干预能显著提高患者的服药依从性，巩固治疗效果。
목적：탐토우좌필극륭치료만성긴장형두통적림상료효급심리간예대용약의종성적영향。방법장118례만성긴장형두통환자수궤분위대조조화관찰조，각59례。대조조여이내보생치료，관찰조가용우좌필극륭，균진행침대성심리간예，료정균위8주。결과여대조조상비，관찰조치료총유효솔현저제고（ P﹤0.05）；량조환자치료후동통시각모의평분（VAS）。교치료전균유명현하강，관찰조환자자제4주기즉교대조조하강현저（ P﹤0.05）；재동통발작지속차수평분방면，관찰조자제4주개시평분교치료전즉유명현하강，이대조조재제6주시재출현현저하강，조간유현저성차이（ P﹤0.05）；재동통지속시간평분방면，관찰조환자재제2주시출현명현하강，대조조칙재제4주시출현명현하강，조간차이현저（ P﹤0.05）；량조환자복약의종솔급약품불량반응발생솔간미견명현차이（ P﹥0.05）。결론우좌필극륭치료만성긴장형두통안전、유효，동시여침대성심리간예능현저제고환자적복약의종성，공고치료효과。
Objective To study the clinical effect of dexzopiclone in the treatment of chronic tension headache and the influence of the psychological intervention on the medication compliance. Methods 118 cases of chronic tension headache were randomly divided into the control group and the observation group, 59 cases in each group. The control group was given the naproxen treatment, while on this basis the observation group was added with dexzopiclone. At the same time the two groups were conducted the targeted psychological intervention and had the treatment course of 8 weeks. Results Compared with the control group, the total effective rate in the obser-vation group was significantly increased, the difference was statistically significant ( P ﹤ 0. 05 ) . The VAS scores after treatment in the two groups were significantly decreased, in which the VAS score in the observation group began to be decreased significantly from 4 weeks as compared with the control group ( P ﹤ 0. 05 ) , but which at 6 weeks in the control group was significantly decreased, the differences between them were statistically significant ( P ﹤ 0. 05 ) . In the aspect of pain persistent time, the score at 2 weeks in the ob-servation group appeared obvious decrease, while which in the control group appeared at 4 weeks, the differences between the two groups were statistically significant ( P ﹤ 0. 05 ) . The medication compliance rate and the incidence rate of adverse reactions had no statistically significant difference between the two groups ( P ﹥ 0. 05 ) . Conclusion Dexzopiclone is effective and safe in the treatment of chronic tension headache, can significantly improve the comfort degree of the patients. The targeted psychological intervention can significantly in-crease the medication compliance of the patients and thus consolidates the treatment effect.