CAJ | 학술논문

目的：探讨不同时期肾综合征出血热（HERS）急性肾损伤（AKI）检测中血清、尿胱抑素C（CYS）的临床价值。方法：收集2010年3月-2012年10月在本院就诊的36例肾综合征出血热患者作为本次研究的观察组，根据临床分期将患者分为发热期/低血压休克期、少尿期、过渡期及多尿期/恢复期；同时选取同期在本院进行健康体检的35名正常体检者作为本次研究的对照组。采用酶法对两组血清肌酐进行测定，采用酶联免疫吸附法对两组血、尿胱抑素C进行测定，对比分析两组血清肌酐，血、尿胱抑素C水平。结果：观察组患者发热期/低血压期、休克期、少尿期、过渡期及多尿期/恢复期血清胱抑素C、尿胱抑素C及血清肌酐水平与对照组比较差异均有统计学意义（P<0.05），且净化组与非净化组血清、血清肌酐及尿胱抑素C比较差异均有统计学意义（P<0.05）。结论：血清及尿胱抑素C都可作为肾综合征出血热急性肾损伤的标志物，可有效反映患者急性肾损伤病情，肾综合征出血热急性肾损伤时尿胱抑素C和肾小管损伤情况更加一致，临床价值显著，可在临床上得到较大范围的推广应用。
목적：탐토불동시기신종합정출혈열（HERS）급성신손상（AKI）검측중혈청、뇨광억소C（CYS）적림상개치。방법：수집2010년3월-2012년10월재본원취진적36례신종합정출혈열환자작위본차연구적관찰조，근거림상분기장환자분위발열기/저혈압휴극기、소뇨기、과도기급다뇨기/회복기；동시선취동기재본원진행건강체검적35명정상체검자작위본차연구적대조조。채용매법대량조혈청기항진행측정，채용매련면역흡부법대량조혈、뇨광억소C진행측정，대비분석량조혈청기항，혈、뇨광억소C수평。결과：관찰조환자발열기/저혈압기、휴극기、소뇨기、과도기급다뇨기/회복기혈청광억소C、뇨광억소C급혈청기항수평여대조조비교차이균유통계학의의（P<0.05），차정화조여비정화조혈청、혈청기항급뇨광억소C비교차이균유통계학의의（P<0.05）。결론：혈청급뇨광억소C도가작위신종합정출혈열급성신손상적표지물，가유효반영환자급성신손상병정，신종합정출혈열급성신손상시뇨광억소C화신소관손상정황경가일치，림상개치현저，가재림상상득도교대범위적추엄응용。
Objective:To investigate the clinical value of serum and urinary cystatin C (CYS) in the different period of hemorrhagic fever with renal syndrome (HERS) in patients with acute kidney injury (AKI).Method:From March 2010 to October 2012 in our hospital,36 cases of renal syndrome hemorrhagic fever were selected as observation group in this study, 36 cases of specimens were also selected as the basis to clinical stage and were divided into the heating period/hypotension shock stage,oliguria stage,transition stage and polyuria period/recovery period;at the same time were selected for health examination in our hospital in 35 normal subjects as control group in this study.Serum creatinine in two groups of subjects was determined by enzymatic method,using enzyme-linked immunosorbent assay for two groups of subjects,blood urine cystatin C were determined,and the structure determination of two groups of patients were analyzed.Result:In period of fever period/hypotension,shock stage,less urine period,transition period and diuresis/recovery phase,serum cystatin C,urine cystatin C and serum creatinine level had significant difference between the observation group and the control group(P<0.05),and there were statistically significant differences in the serum,serum creatinine and urinary cystatin C between the purification group and no purification group(P<0.05).Conclusion:Markers in serum and urine cystatin C as hemorrhagic fever with renal syndrome of acute kidney injury,can effectively respond to the severity of acute kidney injury in patients,renal syndrome of urinary cystatin C and renal tubular injury more consistent hemorrhagic fever of acute kidney injury,clinical value is significant,can be widely used in large range in the clinical.