CAJ | 학술논문

背景：骨髓间充质干细胞具有多向分化潜能，其中磁场对骨髓间充质干细胞分化的影响近年来吸引了相当多的关注。目的：综述磁场对骨髓间充质干细胞向成骨细胞、软骨细胞、脂肪细胞、神经细胞和心肌细胞方向分化的影响，为组织工程种子细胞的研究应用和临床应用磁场的治疗提供参考。方法：由第一作者检索2000至2015年PubMed 数据库以及中国知网数据库有关磁场对骨髓间充质干细胞分化影响的文献，并进行系统整理、总结和分析，最终保留40篇文献进行分析。结果与结论：磁场可以促进骨髓间充质干细胞向成骨细胞、软骨细胞、神经细胞和心肌细胞等方向的分化，可以抑制骨髓间充质干细胞向脂肪细胞方向分化。磁场对骨髓间充质干细胞的诱导分化作用有最适频率和磁场强度，一般来说，较低强度、较低频率的磁场有更明显的诱导作用，磁场对骨髓间充质干细胞分化的影响也具有一定的时间依赖性。
배경：골수간충질간세포구유다향분화잠능，기중자장대골수간충질간세포분화적영향근년래흡인료상당다적관주。목적：종술자장대골수간충질간세포향성골세포、연골세포、지방세포、신경세포화심기세포방향분화적영향，위조직공정충자세포적연구응용화림상응용자장적치료제공삼고。방법：유제일작자검색2000지2015년PubMed 수거고이급중국지망수거고유관자장대골수간충질간세포분화영향적문헌，병진행계통정리、총결화분석，최종보류40편문헌진행분석。결과여결론：자장가이촉진골수간충질간세포향성골세포、연골세포、신경세포화심기세포등방향적분화，가이억제골수간충질간세포향지방세포방향분화。자장대골수간충질간세포적유도분화작용유최괄빈솔화자장강도，일반래설，교저강도、교저빈솔적자장유경명현적유도작용，자장대골수간충질간세포분화적영향야구유일정적시간의뢰성。
BACKGROUND:Bone marrow mesenchymal stem cels have the ability to differentiate into a variety of non-hematopoietic tissue cels. Effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels have attracted a lot of attention in recent years. OBJECTIVE:To summarize the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels towards osteoblasts, chondrocytes, adipocytes, nerve cels and cardiomyocytes, which provide references for the research and application of tissue engineering seed cels as wel as the clinical applications of magnetic fields. METHODS:The first author performed a data retrieval of PubMed and CNKI databases from 2000 to 2015 to search the articles addressing the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels, and reviewed the literatures systematicaly. Finaly, 40 articles were chosen for further analysis. RESULTS AND CONCLUSION:Magnetic fields can promote the differentiation of bone marrow mesenchymal stem cels towards osteoblasts, chondrocytes, nerve cels and cardiomyocytes, and inhibit the differentiation of bone marrow mesenchymal stem cels towards adipocytes. There are optimal frequency and intensity in the induction of magnetic fields on the differentiation of bone marrow mesenchymal stem cels. In general, low-intensity and low-frequency magnetic fields have more obvious effects on bone marrow mesenchymal stem cels. The facilitation of magnetic fields on the differentiation of bone marrow mesenchymal stem cels is also a time-dependent behavior.