CAJ | 학술논문

目的：探讨2型糖尿病患者体脂分布特点与颈动脉内膜中层厚度（IMT）、血清瘦素水平的关系。方法：选择76例2型糖尿病患者（2型糖尿病组）和34例健康体检者（对照组），测量腰围（WC）、臀围（HC）、体重（W）、全身脂肪含量（BF）、躯干脂肪含量（TrF）、上肢脂肪含量（UF）、下肢脂肪含量（LF），并计算腰臀比（WHR）、BF%、TrF/BF。并检测IMT、血清瘦素水平。比较两组患者上述各指标的差异，并分析体脂分布、体脂成分及血清瘦素水平于IMT的关系。结果：2型糖尿病组患者WC、WHR、BMI、BF、TrF、UF、LF、BF%、TrF/BF、IMT、血清瘦素水平均明显高于对照组（P<0.05）；Pearson相关性分析显示，BF、TrF、UF、LF、BF%、TrF/BF与IMT、血清瘦素水平均呈正相关（P<0.05），血清瘦素水平与IMT呈正相关（P<0.05）；多元线性回归分析显示，TrF/BF、瘦素是IMT的独立危险因素。结论：2型糖尿病患者的体脂分布存在异常，IMT、血清瘦素水平明显升高，且两者均与脂肪分布特点密切相关。
목적：탐토2형당뇨병환자체지분포특점여경동맥내막중층후도（IMT）、혈청수소수평적관계。방법：선택76례2형당뇨병환자（2형당뇨병조）화34례건강체검자（대조조），측량요위（WC）、둔위（HC）、체중（W）、전신지방함량（BF）、구간지방함량（TrF）、상지지방함량（UF）、하지지방함량（LF），병계산요둔비（WHR）、BF%、TrF/BF。병검측IMT、혈청수소수평。비교량조환자상술각지표적차이，병분석체지분포、체지성분급혈청수소수평우IMT적관계。결과：2형당뇨병조환자WC、WHR、BMI、BF、TrF、UF、LF、BF%、TrF/BF、IMT、혈청수소수평균명현고우대조조（P<0.05）；Pearson상관성분석현시，BF、TrF、UF、LF、BF%、TrF/BF여IMT、혈청수소수평균정정상관（P<0.05），혈청수소수평여IMT정정상관（P<0.05）；다원선성회귀분석현시，TrF/BF、수소시IMT적독립위험인소。결론：2형당뇨병환자적체지분포존재이상，IMT、혈청수소수평명현승고，차량자균여지방분포특점밀절상관。
Objective:To discuss the relationship between the characteristics of lipid body distribution and carotid artery intima-media thickness in patients with type 2 diabetic.Method:76 patients with type 2 diabetes mellitus(type 2 diabetes group) and 34 healthy subjects (control group) were enrolled in this study.WC,HC,W,BF,TrF,UF,LF,IMT,serum leptin levels were detected,and WHR,BF%,TrF/BF were calculated.Differences of the above indexes between the two groups were compared,and the relationship between the characteristics of lipid body distribution and carotid artery intima-media thickness on patients with type 2 diabetic were analyzed.Result:WC,WHR,BMI,BF,TrF,UF,LF,BF%,TrF/BF, IMT,serum leptin levels of patients with type 2 diabetes were significantly higher than those of control group(P<0.05).Pearson correlation analysis showed that BF,TrF,UF,LF,BF%,TrF/BF were positively correlated with IMT,serum leptin levels (P<0.05),serum leptin level was positively correlated with IMT(P<0.05).Multiple regression analysis showed that TrF/BF and leptin were the independent risk factors of IMT.Conclusion:The distribution of body fat in patients with type 2 diabetes mellitus are abnormal,IMT and leptin increase significantly,and IMT and leptin are closely related with fat distribution characteristics.