CAJ | 학술논문

目的：了解某院门诊患者中成药处方药品超说明书用药情况，规范临床用药行为。方法对2013年3月至2014年2月该院门诊中成药处方随机抽样，判断超说明书用药情况，并进行统计。结果抽取4600张门诊中成药处方，其中超说明书用药共102张，占2.22％。门诊患者中成药处方超说明书用药情况较少见，以给药剂量和频次与说明书不符的情况比较普遍。中医科、妇产科中成药超说明书处方占比较高，但中医科多为合理用药。结论临床治疗过程中，因特殊医疗需要，超说明书用药偶有存在。临床医师应严格掌握超说明书用药的适用范围，借鉴国内外经验，确保临床用药安全、有效、经济、合理。
목적：료해모원문진환자중성약처방약품초설명서용약정황，규범림상용약행위。방법대2013년3월지2014년2월해원문진중성약처방수궤추양，판단초설명서용약정황，병진행통계。결과추취4600장문진중성약처방，기중초설명서용약공102장，점2.22％。문진환자중성약처방초설명서용약정황교소견，이급약제량화빈차여설명서불부적정황비교보편。중의과、부산과중성약초설명서처방점비교고，단중의과다위합리용약。결론림상치료과정중，인특수의료수요，초설명서용약우유존재。림상의사응엄격장악초설명서용약적괄용범위，차감국내외경험，학보림상용약안전、유효、경제、합리。
Objective To understand the off-label use situation of Chinese patent medicines in a among outpatients in a hospital for standardizing the clinical medication behavior. Methods The Chinese medicine prescriptions in the outpatient department from March 2013 to February 2014 were randomly sampled. The off-label drug use situation was judged according to the instructions contents. The total off-label drug use proportion, off-label drug use in each department, different off-label used drug types, etc. were performed the statistics. Results Totally 4 600 pieces of outpatient Chinese patent medicine prescriptions were extracted, in which 102 pieces of pre-scription were involved off-label use, accounting for 2. 22%. Among the outpatients, the off-label use of Chinese patent medicine was relatively rare, the situation of the dosage and drug administration frequency un-conforming to the drug instruction were relatively com-mon. The occurrence rate of off-label drug use in the Chinese medicine department and the obstetrics and gynecology department was highest, but the most of which in the Chinese medicine department were the rational off-label use. Conclusion In the process of clin-ical treatment, due to special medical needs, off-label drug use occasionally exists. Clinicians should strictly master the applicable scope of off-label drug use by taking the experiences at home and abroad as reference, to ensure safe, effective, economic and reasonable clinical drug use.