CAJ | 학술논문

目的：研究替加环素、多粘菌素B和头孢哌酮舒巴坦对多重耐药鲍曼不动杆菌体外的抗菌活性，为临床合理用药提供依据。方法：收集2013年1月-2014年6月广东省第二中医院检验科微生物室临床致病菌培养加药敏试验的标本，结果经鉴定为多重耐药鲍曼不动杆菌50株，用药敏纸片扩散法分别对替加环素、多粘菌素和头孢哌酮舒巴坦进行体外药敏试验。结果：替加环素对多重耐药鲍曼不动杆菌保持敏感性100%，对多粘菌素B中介敏感性为67%，对头孢哌酮舒巴坦的耐药率为73%。结论：替加环素、多粘菌素对多重耐药鲍曼不动杆菌有较高的抗菌活性，是临床治疗多重耐药鲍曼不动杆菌感染的最佳药物之一。
목적：연구체가배소、다점균소B화두포고동서파탄대다중내약포만불동간균체외적항균활성，위림상합리용약제공의거。방법：수집2013년1월-2014년6월광동성제이중의원검험과미생물실림상치병균배양가약민시험적표본，결과경감정위다중내약포만불동간균50주，용약민지편확산법분별대체가배소、다점균소화두포고동서파탄진행체외약민시험。결과：체가배소대다중내약포만불동간균보지민감성100%，대다점균소B중개민감성위67%，대두포고동서파탄적내약솔위73%。결론：체가배소、다점균소대다중내약포만불동간균유교고적항균활성，시림상치료다중내약포만불동간균감염적최가약물지일。
Objective:To study the tigecycline,polymyxin B and cefoperazone sulbactam motionless bacilli in vitro antibacterial activity against multi drug resistant Bauman acinetobacter,to provide the basis for clinical rational drug use. Method:The clinical microbiology laboratory bacteria cultures of drug sensitivity test specimens were selected in our hospital from January 2013 to June 2014,the results identified by the multi drug resistance of 50 strains of Bauman Acinetobacter,drug sensitivity disk diffusion method were used to tigecycline,polymyxin and cefoperazone sulbactam for in vitro drug sensitivity test. Result:Tigecycline against multi drug resistant acinetobacter keep Bauman sensitivity of 100%,polymyxin B and moderate sensitivity was 67%,resistant to cefoperazone sulbactam rate was 73%.Conclusion:Tigecycline and polymyxin against multi drug resistant Bauman acinetobacter have high antibacterial activity,is one of the best drug bacillus for the treatment of multi drug resistant acinetobacter Bauman.