CAJ | 학술논문

目的：分析治疗慢性阻塞性肺疾病( COPD )合并糖尿病患者最佳的糖皮质激素应用剂量。方法回顾性分析北京军区北戴河疗养院2004-01—2012-01收治的600例COPD合并糖尿病患者的临床资料。将患者分为3组，即低剂量、中等剂量和高剂量糖皮质激素治疗组。观察患者接受治疗后肺功能及并发症情况。结果3组患者在治疗后12个月监测肺功能，VC、FVC、FEV1、FEV1/FVC四项功能指标组间差异均无统计学意义(P＞0.05)；然而治疗后随访期间，糖皮质激素剂量依赖性糖尿病相关并发症累计发生次数在高剂量组明显高于中等剂量组及低剂量组(P＜0.05)。结论中、低剂量糖皮质激素治疗COPD合并糖尿病的患者既能达到治疗效果，同时能明显减少患者糖尿病相关并发症的发生率。
목적：분석치료만성조새성폐질병( COPD )합병당뇨병환자최가적당피질격소응용제량。방법회고성분석북경군구북대하요양원2004-01—2012-01수치적600례COPD합병당뇨병환자적림상자료。장환자분위3조，즉저제량、중등제량화고제량당피질격소치료조。관찰환자접수치료후폐공능급병발증정황。결과3조환자재치료후12개월감측폐공능，VC、FVC、FEV1、FEV1/FVC사항공능지표조간차이균무통계학의의(P＞0.05)；연이치료후수방기간，당피질격소제량의뢰성당뇨병상관병발증루계발생차수재고제량조명현고우중등제량조급저제량조(P＜0.05)。결론중、저제량당피질격소치료COPD합병당뇨병적환자기능체도치료효과，동시능명현감소환자당뇨병상관병발증적발생솔。
Objective To discuss the best dosage of glucocorticoid application to treat severe COPD sufferers com-plicated with diabetes.Methods The clinical data of 600 COPD sufferers com plicated with diabetes adm itted to Bei-daihe Sanatorium of Beijing Military R egion from January 2004 to January 2012 were retrospectively analyzed.A ll suf-ferers were divided into three groups according to the dosage of glucocorticoid:low-dosage group ,m oderate-dosage group and high-dosage group .The lung functions and com plications of the sufferers after treatm ent were evaluated . Results A fter 12 m onths treatm ent,the lung functions of the three groups were m onitored ,and the differences of four functional param eters including VC ,FVC ,FEV1,and FEV1/FVC had no statistical significance(P>0.05).H owever,dur-ing the follow-up visit after treatm ent,it was found that the glucocorticoid dose-dependent diabetes com plications rate in the high-dosage group was clearly higher than the other two groups significantly (P<0 .05 ).Conclusion The treat-m ent effect with low-doage and m oderate-dosage of glucocorticoid to treat COPD sufferers com plicated with diabetes was satisfactory,and it can clearly reduce the diabetes-related com plication rate.