CAJ | 학술논문

目的：探讨小剂量甲巯咪唑联合加味知柏地黄汤治疗甲状腺功能亢进的治疗总成本及临床疗效。方法根据随机数字表法将80例患者随机分为治疗组和对照组，各40例。对照组应用常规剂量甲巯咪唑治疗，治疗组给予小剂量甲巯咪唑联合加味知柏地黄汤治疗，疗程均为6个月，且于治疗后随访6个月。结果治疗组总有效率为95.00％，显著高于对照组的72.50％（ P﹤0.05）；治疗后，治疗组总三碘甲状腺原氨酸( TT3)，血清总甲状腺素( TT4)，血清游离甲状腺素T3( FT3)、FT4水平显著低于对照组，促卵泡成熟激素( FSH )显著高于对照组（ P﹤0.05）；治疗过程中治疗组不良反应发生率为7.50％，显著低于对照组的27.50％（ P﹤0.05）；治疗后随访6个月治疗组复发率为2.50％，显著低于对照组的20.00％（ P﹤0.05）；治疗总成本治疗组显著低于对照组（ P﹤0.05）。结论小剂量甲巯咪唑联合加味知柏地黄汤治疗甲状腺功能亢进的治疗总成本低，疗效显著，具有临床应用价值。
목적：탐토소제량갑구미서연합가미지백지황탕치료갑상선공능항진적치료총성본급림상료효。방법근거수궤수자표법장80례환자수궤분위치료조화대조조，각40례。대조조응용상규제량갑구미서치료，치료조급여소제량갑구미서연합가미지백지황탕치료，료정균위6개월，차우치료후수방6개월。결과치료조총유효솔위95.00％，현저고우대조조적72.50％（ P﹤0.05）；치료후，치료조총삼전갑상선원안산( TT3)，혈청총갑상선소( TT4)，혈청유리갑상선소T3( FT3)、FT4수평현저저우대조조，촉란포성숙격소( FSH )현저고우대조조（ P﹤0.05）；치료과정중치료조불량반응발생솔위7.50％，현저저우대조조적27.50％（ P﹤0.05）；치료후수방6개월치료조복발솔위2.50％，현저저우대조조적20.00％（ P﹤0.05）；치료총성본치료조현저저우대조조（ P﹤0.05）。결론소제량갑구미서연합가미지백지황탕치료갑상선공능항진적치료총성본저，료효현저，구유림상응용개치。
Objective To investigate the total cost and clinical effect of a small dose of methimazole combined Zhibaidihuang Decoction in treating hyperthyroidism. Methods 80 patients with hyperthyroidism were randomly divided into the treatment group and the control groups according to the random number table, 40 cases in each group. The control group received the methimazole therapy, while the treatment group was treated with small dose of methimazole combined with Zhibaidihuang Decoction. The treatment in the two groups lasted for 6 months and the 6-month follow-up was conducted after treatment. Results The total effective rate in the treatment group was 95. 00%, which was significantly higher than 72. 50% in the control group with statistical difference ( P ﹤ 0. 05 );the TT3, TT4, FT3 and FT4 levels after treatment in the treatment group were significantly lower than those in the control group, while the FSH level was significantly higher nthan that in the control group, the differences were statistically significant ( P ﹤ 0. 05 );the incidence rate of adverse reactions during treatment in the treatment group was 7. 50%, which was significantly lower than 27. 50% in the control group, the dif-ference was statistical significant ( P ﹤ 0. 05 ); the relapse rate during 6-month follow-up after treatment in the treatment group was 2. 50%, which was significantly lower than 20. 00% in the control group, showing statistically significant difference between them ( P ﹤0. 05 );the total cost of the treatment group was significantly less than that in the control group with statistically significant difference ( P ﹤ 0. 05 ) . Conclusion Low-dose of methimazole combined with modified Zhibaidihuang Decoction in treating hyperthyroidism has low total cost, significant effect and important clinical research value.