中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
13期
16-16,17
,共2页
王林丽%杨巧虹%李卓恒%卢来春%吕金胜
王林麗%楊巧虹%李卓恆%盧來春%呂金勝
왕림려%양교홍%리탁항%로래춘%려금성
乳宁口服液%乳腺增生%大鼠模型%性激素
乳寧口服液%乳腺增生%大鼠模型%性激素
유저구복액%유선증생%대서모형%성격소
Runing Oral Liquid%hyperplasia of mammary glands%rat model%sex hormone
目的:研究乳宁口服液对大鼠乳腺增生的治疗作用。方法建立乳腺增生大鼠模型,灌胃给药乳宁口服液,观察低、中、高剂量[0.5,2.5,5.0 mL/( kg·d )]组大鼠的行为学改变、乳房情况,以及血液中激素水平的变化。结果低、中、高剂量乳宁口服液均能显著改善乳腺增生大鼠模型行为学异常、乳房情况,以及血液中雌二醇(E2)、孕酮(P )、催乳素(PRL )水平( P﹤0.01),且呈一定的量效关系。结论乳宁口服液对乳腺增生有一定治疗作用。
目的:研究乳寧口服液對大鼠乳腺增生的治療作用。方法建立乳腺增生大鼠模型,灌胃給藥乳寧口服液,觀察低、中、高劑量[0.5,2.5,5.0 mL/( kg·d )]組大鼠的行為學改變、乳房情況,以及血液中激素水平的變化。結果低、中、高劑量乳寧口服液均能顯著改善乳腺增生大鼠模型行為學異常、乳房情況,以及血液中雌二醇(E2)、孕酮(P )、催乳素(PRL )水平( P﹤0.01),且呈一定的量效關繫。結論乳寧口服液對乳腺增生有一定治療作用。
목적:연구유저구복액대대서유선증생적치료작용。방법건립유선증생대서모형,관위급약유저구복액,관찰저、중、고제량[0.5,2.5,5.0 mL/( kg·d )]조대서적행위학개변、유방정황,이급혈액중격소수평적변화。결과저、중、고제량유저구복액균능현저개선유선증생대서모형행위학이상、유방정황,이급혈액중자이순(E2)、잉동(P )、최유소(PRL )수평( P﹤0.01),차정일정적량효관계。결론유저구복액대유선증생유일정치료작용。
Objective To study the effect of Runing Oral Liquid in treating hyperplasia of mammary glands in rats. Methods The rat model of hyperplasia of mammary glands s was established. The behavioral changes, mammary tissue and levels of serum hormones in rats were observed after administration of Runing Oral Liquid [0. 5, 2. 5, 5. 0 mL/ (kg·d) ] by gavage. Results The low-, medium-, high-dose of Runing Oral Liquid could remarkably improve the behavioral abnormality, breast status and levels of serum estradiol ( E2 ) , progesterone ( P ) and prolactin ( PRL ) in rats with hyperplasia of mammary glands ( P ﹤ 0. 01 ) . Conclusion Runing Oral Liquid has certain therapeutic effect on hyperplasia of mammary glands.