中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
23期
3692-3697
,共6页
干细胞%移植%血栓闭塞性脉管炎%自体骨髓干细胞%疼痛%冷感%间歇性跛行%长期疗效%新疆维吾尔自治区自然科学基金
榦細胞%移植%血栓閉塞性脈管炎%自體骨髓榦細胞%疼痛%冷感%間歇性跛行%長期療效%新疆維吾爾自治區自然科學基金
간세포%이식%혈전폐새성맥관염%자체골수간세포%동통%랭감%간헐성파행%장기료효%신강유오이자치구자연과학기금
Myeloid Progenitor Cells%Transplantation,Autologous%Thromboangiitis,Obliterans%Treatment Outcome
背景：慢性缺血性疾病的长期疗效评估较短期疗效评估更为重要，关系患者远期生活质量及长期生存率。目的：分析自体骨髓干细胞移植治疗血栓闭塞性脉管炎的5年随访结果。方法：收集新疆医科大学第一附属医院血管甲状腺外科自2007年8月至2010年1月行自体骨髓干细胞移植的血栓闭塞性脉管炎患者43例。移植后1，2，3，4，5年电话定期随访疼痛、冷感、间歇性跛行距离，并观察患肢溃疡的变化情况。移植后1年复查患肢静脉血氧分压和血氧饱和度。结果与结论：有完整随访资料的血栓闭塞性脉管炎患者38例进入结果分析。38例患者的疼痛、冷感、间歇性跛行情况较移植前明显好转，差异有显著性意义(Z值分别为-4.277、-5.086、-3.574，P <0.001)。移植后1-5年间相比，患者的疼痛、冷感情况差异无显著性意义(P >0.05)，间歇性跛行距离逐渐增加，差异有显著性意义(Z=43.898，P<0.001)。患肢静脉血氧分压和血氧饱和度移植前与移植后1年对比差异有显著性意义(t值分别为36.790、43.964，P值分别为0.040、0.037)。以上结果表明自体骨髓干细胞移植治疗血栓闭塞性脉管长期效果稳定。
揹景：慢性缺血性疾病的長期療效評估較短期療效評估更為重要，關繫患者遠期生活質量及長期生存率。目的：分析自體骨髓榦細胞移植治療血栓閉塞性脈管炎的5年隨訪結果。方法：收集新疆醫科大學第一附屬醫院血管甲狀腺外科自2007年8月至2010年1月行自體骨髓榦細胞移植的血栓閉塞性脈管炎患者43例。移植後1，2，3，4，5年電話定期隨訪疼痛、冷感、間歇性跛行距離，併觀察患肢潰瘍的變化情況。移植後1年複查患肢靜脈血氧分壓和血氧飽和度。結果與結論：有完整隨訪資料的血栓閉塞性脈管炎患者38例進入結果分析。38例患者的疼痛、冷感、間歇性跛行情況較移植前明顯好轉，差異有顯著性意義(Z值分彆為-4.277、-5.086、-3.574，P <0.001)。移植後1-5年間相比，患者的疼痛、冷感情況差異無顯著性意義(P >0.05)，間歇性跛行距離逐漸增加，差異有顯著性意義(Z=43.898，P<0.001)。患肢靜脈血氧分壓和血氧飽和度移植前與移植後1年對比差異有顯著性意義(t值分彆為36.790、43.964，P值分彆為0.040、0.037)。以上結果錶明自體骨髓榦細胞移植治療血栓閉塞性脈管長期效果穩定。
배경：만성결혈성질병적장기료효평고교단기료효평고경위중요，관계환자원기생활질량급장기생존솔。목적：분석자체골수간세포이식치료혈전폐새성맥관염적5년수방결과。방법：수집신강의과대학제일부속의원혈관갑상선외과자2007년8월지2010년1월행자체골수간세포이식적혈전폐새성맥관염환자43례。이식후1，2，3，4，5년전화정기수방동통、랭감、간헐성파행거리，병관찰환지궤양적변화정황。이식후1년복사환지정맥혈양분압화혈양포화도。결과여결론：유완정수방자료적혈전폐새성맥관염환자38례진입결과분석。38례환자적동통、랭감、간헐성파행정황교이식전명현호전，차이유현저성의의(Z치분별위-4.277、-5.086、-3.574，P <0.001)。이식후1-5년간상비，환자적동통、랭감정황차이무현저성의의(P >0.05)，간헐성파행거리축점증가，차이유현저성의의(Z=43.898，P<0.001)。환지정맥혈양분압화혈양포화도이식전여이식후1년대비차이유현저성의의(t치분별위36.790、43.964，P치분별위0.040、0.037)。이상결과표명자체골수간세포이식치료혈전폐새성맥관장기효과은정。
BACKGROUND:The assessment for long-term efficacy of chronic ischemic disease is more important than the short-term efficacy assessment, which associates with patient’s long-term quality of life and long-term survival rate. OBJECTIVE:To observe the 5-year folow-up outcomes of autologous bone marrow stem cel transplantation for the treatment of thromboangitis obliterans. METHODS:This study enroled 43 patients of thromboangitis obliterans who underwent autologous bone marrow stem cel transplantation from August 2007 to January 2010 in the Department of Thyroid Vascular Surgery, the First Affiliated Hospital of Xinjiang Medical University. At 1, 2, 3, 4 and 5 years after transplantation, pain, cold sensation, and intermittent claudication distance were folowed up by telephone; changes in limb ulcers were observed. At 1 year after transplantation, venous oxygen partial pressure and oxygen saturation of limbs were reviewed. RESULTS AND CONCLUSION:A total of 38 thromboangitis obliterans patients with complete folow-up data were included in the final analysis. Compared to the preoperation, pain, cold sensation, and intermittent claudication significantly improved. The difference was statisticaly significant (Z values:-4.277,-5.086,-3.574, P < 0.001). Compared with 1-5 years after operation, pain and cold sensation had no statisticaly difference (P >0.05). Intermittent claudication distance had increased. Differences in terms of intermittent claudication distance was statisticaly significant (Z=43.898,P < 0.001). Significant differences in venous oxygen partial pressure and oxygen saturation were detected between preoperation and 1-year posttransplantation (tvalues: 36.790, 43.964,P values: 0.040, 0.037). Above results suggest that autologous bone marrow stem cel transplantation for thromboangitis obliterans obtained stable long-term outcomes.
