中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
23期
3669-3673
,共5页
干细胞%肿瘤干细胞%胃癌%表面标记物%CD44蛋白%肿瘤浸润%淋巴结转移
榦細胞%腫瘤榦細胞%胃癌%錶麵標記物%CD44蛋白%腫瘤浸潤%淋巴結轉移
간세포%종류간세포%위암%표면표기물%CD44단백%종류침윤%림파결전이
Stomach Neoplasms%Neoplastic Stem Cells%Antigens,CD44
背景:肿瘤干细胞不仅能启动肿瘤发生,还参与肿瘤细胞的侵袭和转移。对肿瘤干细胞来说,识别其特异性细胞表面标志物已成为研究热点。目的:探讨肿瘤干细胞表面标记物CD44在胃癌浸润和淋巴结转移中的临床意义。方法:采用免疫组化 SABC法检测胃癌组织标本CD44蛋白表达,应用Pearsonχ2检验和Cox回归多因素分析,确定CD44表达与胃癌生物学特性及其预后的相关性。结果与结论:100例胃癌标本中,59例(59.0%)标本CD44蛋白呈阳性表达。CD44蛋白在距胃癌原发灶边缘5 cm以上的正常胃黏膜组织中呈阴性表达。胃癌组织中CD44蛋白广泛表达,主要表达于细胞膜,少量表达于细胞浆。胃癌组织中 CD44蛋白的表达和患者性别、年龄无关(P >0.05),但与肿瘤分期和淋巴管浸润、组织学分级、肿瘤大小等有关(P <0.05),其中,肿瘤浸润越深、组织学分级越高、肿瘤直径越大、有淋巴结转移,则CD44蛋白表达阳性率越高,CD44阳性表达是影响患者术后生存的独立预后因素(P <0.05)。以上结果表明肿瘤干细胞表面标记物 CD44在胃癌组织中的表达与胃癌的浸润和淋巴结转移密切相关,表达越高患者预后越差。
揹景:腫瘤榦細胞不僅能啟動腫瘤髮生,還參與腫瘤細胞的侵襲和轉移。對腫瘤榦細胞來說,識彆其特異性細胞錶麵標誌物已成為研究熱點。目的:探討腫瘤榦細胞錶麵標記物CD44在胃癌浸潤和淋巴結轉移中的臨床意義。方法:採用免疫組化 SABC法檢測胃癌組織標本CD44蛋白錶達,應用Pearsonχ2檢驗和Cox迴歸多因素分析,確定CD44錶達與胃癌生物學特性及其預後的相關性。結果與結論:100例胃癌標本中,59例(59.0%)標本CD44蛋白呈暘性錶達。CD44蛋白在距胃癌原髮竈邊緣5 cm以上的正常胃黏膜組織中呈陰性錶達。胃癌組織中CD44蛋白廣汎錶達,主要錶達于細胞膜,少量錶達于細胞漿。胃癌組織中 CD44蛋白的錶達和患者性彆、年齡無關(P >0.05),但與腫瘤分期和淋巴管浸潤、組織學分級、腫瘤大小等有關(P <0.05),其中,腫瘤浸潤越深、組織學分級越高、腫瘤直徑越大、有淋巴結轉移,則CD44蛋白錶達暘性率越高,CD44暘性錶達是影響患者術後生存的獨立預後因素(P <0.05)。以上結果錶明腫瘤榦細胞錶麵標記物 CD44在胃癌組織中的錶達與胃癌的浸潤和淋巴結轉移密切相關,錶達越高患者預後越差。
배경:종류간세포불부능계동종류발생,환삼여종류세포적침습화전이。대종류간세포래설,식별기특이성세포표면표지물이성위연구열점。목적:탐토종류간세포표면표기물CD44재위암침윤화림파결전이중적림상의의。방법:채용면역조화 SABC법검측위암조직표본CD44단백표체,응용Pearsonχ2검험화Cox회귀다인소분석,학정CD44표체여위암생물학특성급기예후적상관성。결과여결론:100례위암표본중,59례(59.0%)표본CD44단백정양성표체。CD44단백재거위암원발조변연5 cm이상적정상위점막조직중정음성표체。위암조직중CD44단백엄범표체,주요표체우세포막,소량표체우세포장。위암조직중 CD44단백적표체화환자성별、년령무관(P >0.05),단여종류분기화림파관침윤、조직학분급、종류대소등유관(P <0.05),기중,종류침윤월심、조직학분급월고、종류직경월대、유림파결전이,칙CD44단백표체양성솔월고,CD44양성표체시영향환자술후생존적독립예후인소(P <0.05)。이상결과표명종류간세포표면표기물 CD44재위암조직중적표체여위암적침윤화림파결전이밀절상관,표체월고환자예후월차。
BACKGROUND:Tumor stem cels not only initiate tumorigenesis, but also are involved in the invasion and metastasis of tumor cels. For tumor stem cels, to identify the specific cel surface marker has become a research hotspot. OBJECTIVE:To explore the clinical significance of cancer stem cel surface marker CD44 in gastric cancer invasion and lymph node metastasis. METHODS: CD44 protein expression in specimens of gastric cancer tissue was detected by the immunohistochemical SABC method. The relationship between CD44 protein expression and biological characteristics and prognosis of gastric cancer was detected using Pearsonχ2 test and Cox regression analysis. RESULTS AND CONCLUSION:Among 100 cases of gastric carcinoma, 59 cases (59%) were positive for CD44 protein expression. CD44 protein expression in normal gastric mucosa at above 5 cm from the edge of primary gastric cancer was negative. CD44 protein was widely expressed in tissues of gastric cancer, mainly expressed in the cel membrane, and a smal amount of expression in the cytoplasm. CD44 protein expression in gastric cancer tissue was not correlated with sex of the patients or age (P > 0.05), but was associated with tumor staging and lymph duct tissue infiltration, histological grade, and tumor size (P < 0.05). Deep tumor invasion, high histological grade, big diameter of tumor, and lymph node metastasis could lead to high positive CD44 protein expression. Positive expression of CD44 is an independent prognostic factor affecting postoperative survival (P < 0.05). The results show that the cancer stem cel surface markers CD44 in gastric carcinoma tissues is strongly associated with invasion of gastric carcinoma and lymph node metastasis. High expression of CD44 presents poor prognosis.