CAJ | 학술논문

目的：评价芒硝外敷辅助治疗重症急性胰腺炎（severe acute pancreatitis，SAP）的疗效。方法计算机检索 Co－chrane 图书馆、PUBMED、EMBASE、Medline、中国期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、维普数据库（VIP）、万方数据库中有关芒硝辅助治疗 SAP 疗效的随机对照试验，并手工检索相关文献。检索时限均为从建库至2014年12月，无语言和出版物限制。由两位研究者独立进行资料提取和质量评价后，采用 RevMan5．3软件进行 Meta 分析。结果共纳入10个随机对照试验，包括680例患者。 Meta 分析表明：芒硝组腹痛、腹胀缓解时间，发热时间，禁食时间，住院天数均短于对照组，差异有统计学意义（P ＜0．05）。芒硝组并发症发生率低于对照组，差异有统计学意义（P ＝0．02）。两组间死亡率差异无统计学意义（P ＝0．21）。结论芒硝外敷辅助治疗 SAP 能明显缩短患者的腹痛缓解时间、腹胀缓解时间、发热时间、禁食时间、住院时间和并发症发生率。鉴于该系统评价为二次研究，纳入分析的原始文献质量不一，而且评价过程也可能存在偏倚，上述结论尚需进一步开展大规模、高质量的基础和临床研究来验证。
목적：평개망초외부보조치료중증급성이선염（severe acute pancreatitis，SAP）적료효。방법계산궤검색 Co－chrane 도서관、PUBMED、EMBASE、Medline、중국기간전문수거고（CNKI）、중국생물의학문헌수거고（CBM）、유보수거고（VIP）、만방수거고중유관망초보조치료 SAP 료효적수궤대조시험，병수공검색상관문헌。검색시한균위종건고지2014년12월，무어언화출판물한제。유량위연구자독립진행자료제취화질량평개후，채용 RevMan5．3연건진행 Meta 분석。결과공납입10개수궤대조시험，포괄680례환자。 Meta 분석표명：망초조복통、복창완해시간，발열시간，금식시간，주원천수균단우대조조，차이유통계학의의（P ＜0．05）。망초조병발증발생솔저우대조조，차이유통계학의의（P ＝0．02）。량조간사망솔차이무통계학의의（P ＝0．21）。결론망초외부보조치료 SAP 능명현축단환자적복통완해시간、복창완해시간、발열시간、금식시간、주원시간화병발증발생솔。감우해계통평개위이차연구，납입분석적원시문헌질량불일，이차평개과정야가능존재편의，상술결론상수진일보개전대규모、고질량적기출화림상연구래험증。
Objective To assess the efficacy of natrii sulfas in the adjuvant treatment of severe acute pancreatitis .Methods Published randomized controlled trials (RCTs)of natrii sulfas in the adjuvant treatment of severe acute pancreatitis in data -base of Co-chrane library,PUBMED,EMBASE,Medline,CNKI,CBM,VIP and Wanfang Data were searched from the date of establishment of the databases to December 2014.A manual search of relevant journals and conference proceedings were also performed .Two reviewers as-sessed the quality of each included studies according to Cochrane Reviewers ˊHandbook 4.2.2 recommend standard and then extracted data.Meta-analyses were performed with RevMan 5.3 software.Results A total of 10 studies involving 680 cases were included into the analysis.Meta-analysis showed that the relieve time of abdominal pain and distension ,the period of fever,the fasting period and the days of hospitalization stay in the patients treated with natrii sulfas were significantly shorter than that in the control groups( allP <0.05).The incidence of complications in the natrii sulfas group was also lower than that in the control groups (P =0.02).However, there was no significant difference in the rate of hospital mortality (P =0.21).Conclusion Adjunctive therapy of severe acute pancre -atitis with natrii sulfas can decrease the incidence of complications and shorten the duration of abdominal pain and distension ,the period of fever,the period of fasting and hospitalization stay .However,further large-scale and high-quality studies on basic and clinical fields are needed to verify the conclusions because that this study is a secondary study ,and there are the different qualities and the bias of e -valuation process in the original studies ..