中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
19期
49-50,53
,共3页
老年结肠癌%腹腔镜扩大根治术%开腹扩大根治术%肿瘤坏死因子-α%转化生长因子β1%白介素17
老年結腸癌%腹腔鏡擴大根治術%開腹擴大根治術%腫瘤壞死因子-α%轉化生長因子β1%白介素17
노년결장암%복강경확대근치술%개복확대근치술%종류배사인자-α%전화생장인자β1%백개소17
Elderly colon cancer%Laparoscopic extended radical mastectomy%Open extended radical mastectomy%Tu-mor necrosis factor-α%Transforming growth factorβ1%Interleukin-17
目的：探讨腹腔镜结肠癌根治术对患者血清TNF-α、TGF-β1及IL-17的影响。方法将75例老年结肠癌患者按照术式分为对照组(n=37)与观察组(n=38)，分别采用开腹扩大根治术与腹腔镜扩大根治术治疗。比较两组患者术中及术后情况、手术前后血清TNF-α、TGF-β1及IL-17水平、治疗前后生活质量评分。结果(1)观察组患者手术时间、术中出血量、术后排气时间及住院时间均显著小于对照组(P<0.05)；(2)两组术后1 d血清TNF-α、TGF-β1及IL-17水平均显著大于术前(P<0.05)，且观察组术后5 d上述指标水平均显著小于对照组术后5 d时水平，差异均具有统计学意义(P<0.05)。结论腹腔镜扩大根治术与开腹扩大根治术均可增加血清TNF-α、TGF-β1及IL-17水平，但随着时间的推移，腹腔镜扩大根治术患者血清中上述指标逐渐恢复至术前水平，但开腹扩大根治术患者血清上述指标恢复较慢；腹腔镜扩大根治术可有效改善患者预后状况。
目的：探討腹腔鏡結腸癌根治術對患者血清TNF-α、TGF-β1及IL-17的影響。方法將75例老年結腸癌患者按照術式分為對照組(n=37)與觀察組(n=38)，分彆採用開腹擴大根治術與腹腔鏡擴大根治術治療。比較兩組患者術中及術後情況、手術前後血清TNF-α、TGF-β1及IL-17水平、治療前後生活質量評分。結果(1)觀察組患者手術時間、術中齣血量、術後排氣時間及住院時間均顯著小于對照組(P<0.05)；(2)兩組術後1 d血清TNF-α、TGF-β1及IL-17水平均顯著大于術前(P<0.05)，且觀察組術後5 d上述指標水平均顯著小于對照組術後5 d時水平，差異均具有統計學意義(P<0.05)。結論腹腔鏡擴大根治術與開腹擴大根治術均可增加血清TNF-α、TGF-β1及IL-17水平，但隨著時間的推移，腹腔鏡擴大根治術患者血清中上述指標逐漸恢複至術前水平，但開腹擴大根治術患者血清上述指標恢複較慢；腹腔鏡擴大根治術可有效改善患者預後狀況。
목적：탐토복강경결장암근치술대환자혈청TNF-α、TGF-β1급IL-17적영향。방법장75례노년결장암환자안조술식분위대조조(n=37)여관찰조(n=38)，분별채용개복확대근치술여복강경확대근치술치료。비교량조환자술중급술후정황、수술전후혈청TNF-α、TGF-β1급IL-17수평、치료전후생활질량평분。결과(1)관찰조환자수술시간、술중출혈량、술후배기시간급주원시간균현저소우대조조(P<0.05)；(2)량조술후1 d혈청TNF-α、TGF-β1급IL-17수평균현저대우술전(P<0.05)，차관찰조술후5 d상술지표수평균현저소우대조조술후5 d시수평，차이균구유통계학의의(P<0.05)。결론복강경확대근치술여개복확대근치술균가증가혈청TNF-α、TGF-β1급IL-17수평，단수착시간적추이，복강경확대근치술환자혈청중상술지표축점회복지술전수평，단개복확대근치술환자혈청상술지표회복교만；복강경확대근치술가유효개선환자예후상황。
Objective To evaluate laparoscopic radical of serum TNF-α, TGF-β1 and IL-17 affects the surgery. Methods A total of 75 cases elderly colon cancer patients were divided into two groups according to surgical, control group (n=37) and the observation group (n=38), respectively, to expand the use of open and laparoscopic radical resec-tion extended radical mastectomy treatment. The intraoperative and postoperative conditions, serum TNF-α, TGF-β1 and IL-17 levels before and after surgery, quality of life scores before and after treatment were compared. Results (1)Surgical patients in the observation group time, blood loss, postoperative exhaust time and hospital stay were signifi-cantly lower than the control group (P<0.05); (2) 1 d postoperative serum TNF-α, TGF-β1 and IL-17 levels were sig-nificantly higher than before surgery (P<0.05), and the index levels of 5 d in observation group were significantly lower than control group after 5 d level, the differences were statistically significant (P<0.05). Conclusion Laparoscopic extended radical mastectomy and extended radical mastectomy can open an increase in serum TNF-α, TGF-β1 and IL-17 levels, but over time, the expansion of radical laparoscopic surgery in patients with serum gradually returned to the index preoperative level, but open extended radical mastectomy in patients with serum above indicators slow recovery;laparoscopic extended radical mastectomy can improve prognosis for patients.
