CAJ | 학술논문

目的：分析急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清胰岛素样生长因子-1(IGF-1)的相关性。方法选取2012年1月~2014年1月期间我院接受治疗的100例急性脑梗死患者为观察组，并选取同期到我院来进行健康检查的50例健康志愿者作为对照组。采用ELISA法对研究对象的IGF-1的水平进行测定，并采用颈动脉彩超对研究对象进行检查，根据检查结果分为斑块稳定组、斑块不稳定组和无斑块组。结果观察组患者的斑块不稳定、斑块稳定、无斑块和总斑块检出率分别为42.0豫、25.0豫、33.0豫和67.0豫，对照组分别为8.0豫、18.0豫、74.0豫和26.0豫，差异具有统计学意义(P<0.05)。无斑块组血清IGF-1水平显著高于斑块稳定组，无斑块组和斑块稳定组的血清IGF-1显著高于斑块不稳定组，差异具有统计学意义(P<0.05)。多组间的比较为单因素方差分析，F=4.158，P=0.006。斑块稳定组和斑块不稳定组两组患者治疗前的神经功能和精神状态差异无统计学意义(P>0.05)，治疗后斑块稳定组患者的神经功能和精神状态显著优于斑块不稳定组，差异具有统计学意义(P<0.05)。结论脑梗死患者具有较高的颈动脉粥样硬化斑块发生率，稳定性颈动脉粥样硬化斑块患者的血清IGF-1水平较高，血清IGF-1水平的减少与不稳定性颈动脉粥样硬化斑块形成有密切联系。
목적：분석급성뇌경사환자경동맥죽양경화반괴은정성여혈청이도소양생장인자-1(IGF-1)적상관성。방법선취2012년1월~2014년1월기간아원접수치료적100례급성뇌경사환자위관찰조，병선취동기도아원래진행건강검사적50례건강지원자작위대조조。채용ELISA법대연구대상적IGF-1적수평진행측정，병채용경동맥채초대연구대상진행검사，근거검사결과분위반괴은정조、반괴불은정조화무반괴조。결과관찰조환자적반괴불은정、반괴은정、무반괴화총반괴검출솔분별위42.0예、25.0예、33.0예화67.0예，대조조분별위8.0예、18.0예、74.0예화26.0예，차이구유통계학의의(P<0.05)。무반괴조혈청IGF-1수평현저고우반괴은정조，무반괴조화반괴은정조적혈청IGF-1현저고우반괴불은정조，차이구유통계학의의(P<0.05)。다조간적비교위단인소방차분석，F=4.158，P=0.006。반괴은정조화반괴불은정조량조환자치료전적신경공능화정신상태차이무통계학의의(P>0.05)，치료후반괴은정조환자적신경공능화정신상태현저우우반괴불은정조，차이구유통계학의의(P<0.05)。결론뇌경사환자구유교고적경동맥죽양경화반괴발생솔，은정성경동맥죽양경화반괴환자적혈청IGF-1수평교고，혈청IGF-1수평적감소여불은정성경동맥죽양경화반괴형성유밀절련계。
Objective To analyze the correlation between the stability of carotid atherosclerostic plaque and serum in-sulin-like growth factor-1 (IGF-1) in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction who were admitted to our hospital from January 2012 to January 2014 were selected as an observa-tion group, and 50 healthy volunteers who received physical examination in our hospital at the same period of time were selected as a control group. ELISA method was applied to measure the level of serum IGF-1 in subjects, and carotid color ultrasonography was applied for examination in subjects. On the basis of the results of examination, the subjects were divided into stable plaque group, instable plaque group and plaque-free group. Results The detection rate of in-stable plaque, stable plaque, plaque-free and total plaque detection rate in the observation group were 42.0%, 25.0%, 33.0% and 67.0% respectively, in the control group were 8.0%, 18.0%, 74.0% and 26.0%. The differences were statis-tically significant (P<0.05). Serum IGF-1 level in the plaque-free group was significantly higher than that in the stable plaque group, and serum IGF-1 level in the plaque-free group and stable plaque group was significantly higher than that in the instable plaque group. The differences were statistically significant (P<0.05). One-way analysis of variance was applied in the comparison between multiple groups, F=4.158, P=0.006. The differences of neurological function and mental states before the treatment in the stable plaque group and instable plaque group were not statistically signifi-cant (P>0.05), and the neurological function and mental states after the treatment in the stable plaque group were signif-icantly better than those in the instable plaque group. The differences were statistically significant (P<0.05). Conclusion Patients with cerebral infarction have relatively higher incidence of carotid atherosclerostic plaque, and patients with stable carotid atherosclerostic plaque have higher serum IGF-1 level. The reduction of serum IGF-1 level is closely correlated with the formation of instable carotid atherosclerostic plaque.