CAJ | 학술논문

目的：观察香菇多糖联合化疗治疗中晚期老年NSCLC患者的临床疗效及安全性。方法收集2011年1月～2013年12月的病例139例，分为治疗组（n=69）和对照组（n=70），治疗组予以香菇多糖联合化疗，对照组予以化疗，比较两组间的差异。结果治疗组生活质量改善的有效率为79.7％，高于对照组的64.3％，差异有统计学意义（P<0.05）。两组的不良反应以血液学毒性、消化道反应为主，其中Ⅲ~Ⅳ度白细胞减少、Ⅱ~Ⅲ度消化道反应的发生率的差异有统计学意义（P<0.05）。治疗组免疫功能较治疗前提高，差异有统计学意义（P<0.05），两组的疾病控制率和无疾病生存期的差异无统计学意义（P>0.05）。结论香菇多糖可以缓解中晚期老年NSCLC患者的化疗毒副反应、提高其临床耐受性，值得临床推广应用。
목적：관찰향고다당연합화료치료중만기노년NSCLC환자적림상료효급안전성。방법수집2011년1월～2013년12월적병례139례，분위치료조（n=69）화대조조（n=70），치료조여이향고다당연합화료，대조조여이화료，비교량조간적차이。결과치료조생활질량개선적유효솔위79.7％，고우대조조적64.3％，차이유통계학의의（P<0.05）。량조적불량반응이혈액학독성、소화도반응위주，기중Ⅲ~Ⅳ도백세포감소、Ⅱ~Ⅲ도소화도반응적발생솔적차이유통계학의의（P<0.05）。치료조면역공능교치료전제고，차이유통계학의의（P<0.05），량조적질병공제솔화무질병생존기적차이무통계학의의（P>0.05）。결론향고다당가이완해중만기노년NSCLC환자적화료독부반응、제고기림상내수성，치득림상추엄응용。
Objective To investigate the efficacy and safety of Lentinan combined with chemotherapy in elderly patients with non-small-cell lung cancer (NSCLC). Methods From January 2011 to December 2013, 139 elderly patients with NSCLC in our hospital were divided into treatment group and control group. Patients in the treatment group (n=69) had chemotherapy combined with Lenti-nan, and patients in the control group (n=70) received chemotherapy only. Then we analyzed and compared the adverse reactions, lym-phocytes subsets, NK cells, quality of life and efficacy between the two groups. Results In the treatment group, 79.7%of patients had their life quality improved, while 64.3%had improvement in control group;there were significant difference between the two groups (P<0.05). The main adverse reactions of both groups included hematologic toxicities and gastrointestinal reaction, but there were statistical difference between the two groups in incidences ofⅢ~Ⅳdegree of leucopenia andⅡ~Ⅲdegree of gastrointestinal reac-tion (P<0.05). The rates of immuno-cells were improved in the treatment group with statistical difference (P<0.05), as compared with those before treatment. There was no statistical difference in disease control rate and progression-free survival between two groups (P>0.05). Conclusion Lentinan combined with chemo-regimen could enhance cellular immune function in patients with NSCLC, im-prove the efficacy of chemotherapy, reduce the side effects and improve quality of life. It deserves application in clinic.