CAJ | 학술논문

目的：探讨乌司他丁对高血压脑出血患者 NSE 浓度和 hs-CRP 的影响及脑保护作用。方法：选取30例高血压脑出血患者为研究对象，随机将其分为对照组与观察组各15例。对照组患者围术期给予常规治疗；观察组患者在对照组基础上应用乌司他丁治疗，比较两组患者手术前后 NIHSS （神经功能缺损评分）、hs-CRP （超敏 C 反应蛋白）、不同时间点（入室时、麻醉诱导后、术后12h、24h、72h）颅内压、NSE 浓度（神经元特异性烯醇化酶）及 GCS （格拉斯哥）评分等情况。结果：观察组术后一周 hs-CRP 水平、NIHSS 评分明显低于对照组，观察组术后12h、24h、72hNSE 浓度明显低于对照组，观察组术后72h 时 GCS 评分明显高于对照组，两组比较差异均有统计学意义（P ＜0．05）。结论：围术期应用乌司他丁能显著降低高血压脑出血患者 hs-CRP、NSE 水平，有利于神经保护、脑损伤减轻。
목적：탐토오사타정대고혈압뇌출혈환자 NSE 농도화 hs-CRP 적영향급뇌보호작용。방법：선취30례고혈압뇌출혈환자위연구대상，수궤장기분위대조조여관찰조각15례。대조조환자위술기급여상규치료；관찰조환자재대조조기출상응용오사타정치료，비교량조환자수술전후 NIHSS （신경공능결손평분）、hs-CRP （초민 C 반응단백）、불동시간점（입실시、마취유도후、술후12h、24h、72h）로내압、NSE 농도（신경원특이성희순화매）급 GCS （격랍사가）평분등정황。결과：관찰조술후일주 hs-CRP 수평、NIHSS 평분명현저우대조조，관찰조술후12h、24h、72hNSE 농도명현저우대조조，관찰조술후72h 시 GCS 평분명현고우대조조，량조비교차이균유통계학의의（P ＜0．05）。결론：위술기응용오사타정능현저강저고혈압뇌출혈환자 hs-CRP、NSE 수평，유리우신경보호、뇌손상감경。
Objective To investigate the effects of ulinastatin on concentrations of NSE and hs -CRP on patients with hypertensive cerebral hemorrhage and brain protection.Methods Select 30 cases of hypertensive cerebral hemorrhage patients as the research ob-ject,were randomly divided into two groups,control group was received routine treatment group patients in the perioperative period, patients in observation group application of ulinastatin treatment based on control group,compared NIHSS (score of nerve functional impairment),hs -CRP (high sensitivity C reactive protein),different points (anesthesia,after anesthesia induction,surgery after 12h,24h,72h),intracranial pressure,NSE (the concentration of neuron specific enolase),GCS (Glasgow)scores etc before and after operation between two groups.Results Observation of hs -CRP level,NIHSS score after one week group were significantly lower than the control group,12h,24h,72h of NSE concentration in observation group were significantly lower than those of the control group,72h GCS score of patients in observation group was significantly higher than that in the control group,difference was statistically significant (P <0.05).Conclusion Perioperative application of ulinastatin can significantly reduce hs -CRP and NSE in patients with hypertensive intracerebral hemorrhage level,is conducive to the protection of nerves,relieve brain injury.