CAJ | 학술논문

目的：探讨 Maspin 在子宫内膜癌中的表达及其与 uPA 的关系。方法采用免疫组化的方法，检测子宫内膜癌50例、子宫内膜不典型增生50例及正常增殖期子宫内膜30例，分析 Maspin 和 uPA 蛋白在其中的表达情况及两者的相关性，以及对子宫内膜癌预后的影响。结果 Maspin 和 uPA 蛋白表达情况在手术病理分期、肌层浸润深度及有无淋巴结转移，差异均有统计学意义（ P <0.05）；且二者的表达呈负相关（ r =-0.341，P <0.05）。结论Maspin 和 uPA 蛋白在子宫内膜癌的发生、发展中发挥重要作用，临床通过联合检测 Maspin 和 uPA 蛋白的表达情况，有助于判断子宫内膜癌的恶性程度和预后。
목적：탐토 Maspin 재자궁내막암중적표체급기여 uPA 적관계。방법채용면역조화적방법，검측자궁내막암50례、자궁내막불전형증생50례급정상증식기자궁내막30례，분석 Maspin 화 uPA 단백재기중적표체정황급량자적상관성，이급대자궁내막암예후적영향。결과 Maspin 화 uPA 단백표체정황재수술병리분기、기층침윤심도급유무림파결전이，차이균유통계학의의（ P <0.05）；차이자적표체정부상관（ r =-0.341，P <0.05）。결론Maspin 화 uPA 단백재자궁내막암적발생、발전중발휘중요작용，림상통과연합검측 Maspin 화 uPA 단백적표체정황，유조우판단자궁내막암적악성정도화예후。
Objective To investigate the expression of Maspin in endometrial tissue of patients with endometrial carcinoma and its relationship with urokinase-type plasminogen activator(uPA)protein. Methods The expression levels of Maspin and uPA protein were detected by immunohistochemicstry(SP)in 50 cases of endometrial carcinoma,50 cases of atypical endometrial hyperplasia and 30 cases of normal endometrial tissues at proliferative phase. The correlation of expression of Maspin and uPA protein between Maspin and uPA and their effects on prognosis of patients with endometrial carcinoma were analyzed. Results The positive expression rates of Maspin protein and uPA protein were closely related with surgical pathological staging,the depth of myometrial infiltration and lymph node metastasis( P < 0. 05),furthermore,the expression of uPA protein was negatively related with that of Maspin protein( r = - 0. 341,P < 0. 05). Conclusion Maspin protein and uPA protein play an important role in the pathogenesis and development of endometrial carcinoma,therefore,the combination detection of expressions of Maspin and UPA protein may contribute to evaluating the malignant degree and prognosis of endometrial carcinoma.