中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
19期
8-11
,共4页
病理性瘢痕%皮肤%Smad%TGF-β1
病理性瘢痕%皮膚%Smad%TGF-β1
병이성반흔%피부%Smad%TGF-β1
Pathologic scar%Skin%Smad%TGF-β1
目的：观察皮肤病理性瘢痕及Smad蛋白和基因的表达情况。方法所有标本来源于2010年4月~2014年4月在我院行瘢痕切除患者和招募的正常志愿者共136例，其中瘢痕疙瘩组47例，增生性瘢痕组44例，正常皮肤组共45例，对所有标本行RT-PCR及流式细胞学检测并分析检测结果。结果从Smad3、TGF-β1基因及其表达情况来看，瘢痕疙瘩组和增生性瘢痕组均高于正常皮肤组，差异有统计学意义(P<0.05)。结论 Smad3和TGF-β1的表达是增生性瘢痕和瘢痕疙瘩的重要特征。
目的：觀察皮膚病理性瘢痕及Smad蛋白和基因的錶達情況。方法所有標本來源于2010年4月~2014年4月在我院行瘢痕切除患者和招募的正常誌願者共136例，其中瘢痕疙瘩組47例，增生性瘢痕組44例，正常皮膚組共45例，對所有標本行RT-PCR及流式細胞學檢測併分析檢測結果。結果從Smad3、TGF-β1基因及其錶達情況來看，瘢痕疙瘩組和增生性瘢痕組均高于正常皮膚組，差異有統計學意義(P<0.05)。結論 Smad3和TGF-β1的錶達是增生性瘢痕和瘢痕疙瘩的重要特徵。
목적：관찰피부병이성반흔급Smad단백화기인적표체정황。방법소유표본래원우2010년4월~2014년4월재아원행반흔절제환자화초모적정상지원자공136례，기중반흔흘탑조47례，증생성반흔조44례，정상피부조공45례，대소유표본행RT-PCR급류식세포학검측병분석검측결과。결과종Smad3、TGF-β1기인급기표체정황래간，반흔흘탑조화증생성반흔조균고우정상피부조，차이유통계학의의(P<0.05)。결론 Smad3화TGF-β1적표체시증생성반흔화반흔흘탑적중요특정。
Objective To observe expressions of Smad gene and protein in skin pathological scar. Methods Every ex-perimental samples were obtained from 136 patients,who underwent scar resection or were recruited healthy people,from April 2010 to April 2014,including 47 patients with keloid,44 patients with hypertrophic scar,45 healthy people. Each sample was taken by RT-PCR and flow cytometry and results were analyzed. Results The expressions of Smad3 and TGF-β1 gene showd that keloid group and hypertrophic scar group were more than normal skin group,the differ-ences were significant(P<0.05). Conclusion The expressions of Smad3 and TGF-β1 are important characters of hyper-trophic scar and keloid.
