CAJ | 학술논문

目前,多数恶性肿瘤常规化疗效果差、预后不良,是困扰临床工作的重要难题,而肿瘤细胞耐药性的产生是导致化疗失败的重要原因之一.经过积极化疗后,残存肿瘤干细胞耐药性的存在,可导致肿瘤细胞对多数化学药物敏感性降低,引起肿瘤复发、转移,最终危及患者生命.肿瘤细胞耐药性的形成机制较为复杂,涉及的信号分子及信号通路相对较多,其具体机制尚未完全阐明.根据目前相关研究,微小RNA(miRNA)与肿瘤耐药性的形成高度相关.miRNA通过对耐药机制进行靶向调节,对减少肿瘤细胞耐药性形成起着非常重要的作用.笔者拟就目前miRNA调控肿瘤细胞耐药机制形成的研究进展进行综述.
목전,다수악성종류상규화료효과차、예후불량,시곤우림상공작적중요난제,이종류세포내약성적산생시도치화료실패적중요원인지일.경과적겁화료후,잔존종류간세포내약성적존재,가도치종류세포대다수화학약물민감성강저,인기종류복발、전이,최종위급환자생명.종류세포내약성적형성궤제교위복잡,섭급적신호분자급신호통로상대교다,기구체궤제상미완전천명.근거목전상관연구,미소RNA(miRNA)여종류내약성적형성고도상관.miRNA통과대내약궤제진행파향조절,대감소종류세포내약성형성기착비상중요적작용.필자의취목전miRNA조공종류세포내약궤제형성적연구진전진행종술.
At present,the poor prognosis of conventional chemotherapy for most malignant tumors is an important problem for clinical work,but the tumor cell resistance is one of the important reasons for the failure of chemotherapy.The existence of tumor stem cell resistance ean cause tumor cells to reduce the sensitivity of most chemical drugs after a positive chemotherapy,the recurrence and metastasis of tumor can ultimately endanger the patient's life.The formation mechanism of drug resistance of tumor cells is complex.And there are many signal molecules and signal transduction pathways related with the formation mechanism of drug resistance,but the concrete mechanism is not yet fully clarified.MicroRNA (miRNA) and the formation of tumor drug resistance are highly correlated according to relevant researches.MiRNA can targetedly regulate drug resistance mechanism and plays a very important role in reducing drug resistance of tumor cells.This article intends to review the research advances of the formation mechanism of miRNA resistant tumor cells.