CAJ | 학술논문

目的：观察华蟾素联合顺铂治疗恶性胸腔积液的临床疗效。方法：基于循证医学评价方法，收集华蟾素联合顺铂治疗恶性胸腔积液的随机对照试验（RCTs），采用 RevMan 5．0软件进行 Meta 分析。结果：共纳入5篇随机对照研究，共373例病例。与单纯顺铂治疗恶性胸腔积液比较，联合华蟾素明显增加恶性胸腔积液治疗效果，提高患者的生活质量，降低骨髓抑制副反应的发生率，但两组胃肠道毒副作用发生率无统计学差异。结论：华蟾素能提高恶性胸腔积液患者的治疗效果，改善生活质量，并降低顺铂化疗药物的毒副作用，值得临床借鉴。
목적：관찰화섬소연합순박치료악성흉강적액적림상료효。방법：기우순증의학평개방법，수집화섬소연합순박치료악성흉강적액적수궤대조시험（RCTs），채용 RevMan 5．0연건진행 Meta 분석。결과：공납입5편수궤대조연구，공373례병례。여단순순박치료악성흉강적액비교，연합화섬소명현증가악성흉강적액치료효과，제고환자적생활질량，강저골수억제부반응적발생솔，단량조위장도독부작용발생솔무통계학차이。결론：화섬소능제고악성흉강적액환자적치료효과，개선생활질량，병강저순박화료약물적독부작용，치득림상차감。
Objective To assess the clinical efficacy and safety of Cinobufacini combined with Cisplatin for malignant pleural effu-sion (MPE),and to provide evidence -based reference for clinica1 use.Methods A comprehensive search strategy was designed to i-dentify all randomized controlled trials (RCTs)comparing Cinobufacini plus Cisplatin chemotherapy with Cisplatin chemotherapy alone MPE by searching database.RevMan 5.0 software was used for statistical analysis.Results Totally 5 RCTs involving 373 patients were included.The Meta -analysis showed that compared with the pure application of Cisplatin therapy,the combination of Cinobufacini and therapy can enhance the near -term curative effect,improve the quality of life and reduce the suppression of bone marrow,and have no significant differences in reducing the gastrointestinal reactions.Conclusion The current evidence indicates that Cinobufacini can enhance the therapeutic effect on MPE patients,improve the quality of life and reduce adverse effect of pure application of Cisplatin therapy and thus it is worth referring in clinic.