实用医院临床杂志
實用醫院臨床雜誌
실용의원림상잡지
PRACTICAL JOURNAL OF CLINICAL MEDICINE
2015年
4期
105-106,107
,共3页
酚妥拉明%西地那非%新生儿肺动脉持续高压
酚妥拉明%西地那非%新生兒肺動脈持續高壓
분타랍명%서지나비%신생인폐동맥지속고압
Phentolamine%Sildenafil%Persistent pulmonary hypertension of the newborn
目的：观察酚妥拉明联合西地那非治疗新生儿肺动脉持续高压（persistent pulmonary hypertension of the new －born，PPHN）的临床疗效。方法2008年5月至2013年7月我院收治的 PPHN 患儿116例，按照随机数字表法分为对照组和观察组各58例，入院后均给予常规基础治疗，其中对照组给予口服西地那非，治疗组给予西地那非联合酚妥拉明治疗，治疗时间为3天，观察两组患儿的氧分压（PaO2）、血氧饱和度（SpO2）、左心室输出量（SV）、肺动脉压（PAP）、临床有效率、使用呼吸机的时间和住院时间。结果与治疗前比较，两组患儿 PO2、SpO2、SV 等指标均明显升高，PAP 明显下降（P ＜0．05）。治疗3天后治疗组患儿的 PO2、SpO2和 SV 指标高于对照组，而 PAP 指标低于对照组，临床有效率（91．4％）高于对照组（81．0％），使用呼吸机时间和住院时间均明显少于对照组，差异均有统计学意义（P ＜0．05）。结论酚妥拉明联合西地那非治疗 PPHN 临床效果显著，患儿各项临床指标改善明显，临床有效率高，值得推广使用。
目的：觀察酚妥拉明聯閤西地那非治療新生兒肺動脈持續高壓（persistent pulmonary hypertension of the new －born，PPHN）的臨床療效。方法2008年5月至2013年7月我院收治的 PPHN 患兒116例，按照隨機數字錶法分為對照組和觀察組各58例，入院後均給予常規基礎治療，其中對照組給予口服西地那非，治療組給予西地那非聯閤酚妥拉明治療，治療時間為3天，觀察兩組患兒的氧分壓（PaO2）、血氧飽和度（SpO2）、左心室輸齣量（SV）、肺動脈壓（PAP）、臨床有效率、使用呼吸機的時間和住院時間。結果與治療前比較，兩組患兒 PO2、SpO2、SV 等指標均明顯升高，PAP 明顯下降（P ＜0．05）。治療3天後治療組患兒的 PO2、SpO2和 SV 指標高于對照組，而 PAP 指標低于對照組，臨床有效率（91．4％）高于對照組（81．0％），使用呼吸機時間和住院時間均明顯少于對照組，差異均有統計學意義（P ＜0．05）。結論酚妥拉明聯閤西地那非治療 PPHN 臨床效果顯著，患兒各項臨床指標改善明顯，臨床有效率高，值得推廣使用。
목적：관찰분타랍명연합서지나비치료신생인폐동맥지속고압（persistent pulmonary hypertension of the new －born，PPHN）적림상료효。방법2008년5월지2013년7월아원수치적 PPHN 환인116례，안조수궤수자표법분위대조조화관찰조각58례，입원후균급여상규기출치료，기중대조조급여구복서지나비，치료조급여서지나비연합분타랍명치료，치료시간위3천，관찰량조환인적양분압（PaO2）、혈양포화도（SpO2）、좌심실수출량（SV）、폐동맥압（PAP）、림상유효솔、사용호흡궤적시간화주원시간。결과여치료전비교，량조환인 PO2、SpO2、SV 등지표균명현승고，PAP 명현하강（P ＜0．05）。치료3천후치료조환인적 PO2、SpO2화 SV 지표고우대조조，이 PAP 지표저우대조조，림상유효솔（91．4％）고우대조조（81．0％），사용호흡궤시간화주원시간균명현소우대조조，차이균유통계학의의（P ＜0．05）。결론분타랍명연합서지나비치료 PPHN 림상효과현저，환인각항림상지표개선명현，림상유효솔고，치득추엄사용。
Objective To investigate clinical effective of phentolamine combined with sildenafil in the treatment of persistent neonatal pulmonary hypertension .Methods One hundred and sixteen neonates with persistent pulmonary hypertension form May 2008 to July 2013 in our hospital were randomly divided into control and treatment groups .All the patients were given conventional treatment after admission.The control group was oral administrated with sildenafil while the treatment group was given sildenafil combined with phentolamine for 3 days.The PO2 ,SpO2 ,SV and PAP were observed.The clinical efficiency,the ventilator time and hospitalization time were compared between the two groups .Results Compared with before treatment,the PO2 ,SpO2 ,SV and other indexes were signifi-cantly increased while PAP was decreased obviously after treatment in the both groups (P <0.05).The PO2 ,SpO2 and SV index in the treatment group were significantly higher while the PAP index was significantly lower than that in the control group (P <0.05).Clini-cal efficiency in the treatment group (91.4%) was higher than that in the control group (81%).The time of ventilator and hospitaliza-tion in the treatment group was significantly less than that in the control group (P <0.05).Conclusion Clinical effective of phento-lamine combined with sildenafil in the treatment of persistent neonatal pulmonary hypertension is obviously .The clinical indicators are improved significantly and the clinical effective rate is high .It is worthy of promotion.
