CAJ | 학술논문

目的：观察冠心病患者血浆可溶性低密度脂蛋白受体相关蛋白1（sLRP1）浓度的变化，并分析其与基质金属蛋白酶9（MMP－9）和高敏 C 反应蛋白（hsCRP）浓度变化的相关性。方法选取2013年8～10月北京安贞医院心内科住院的12例稳定型心绞痛（SAP）、32例急性冠脉综合征（ACS），同期冠脉造影阴性的患者8例为对照组。于介入术前空腹检测血浆 sL－RP1、MMP－9和 hsCRP 的浓度，比较三组之间差异。介入术后第一天空腹检测患者血浆 sLRP1，并与术前相比较，分析冠心病患者 sLRP1与 MMP－9、hsCRP 的相关性。结果术前 ACS 组 sLRP1、MMP－9和 hsCRP 浓度显著高于 SAP 组和对照组，差异有统计学意义（均 P ＜0．01），而 SAP 组和对照组比较差异无统计学意义（P ＞0．05）。 ACS 组患者介入术前和术后 sLRP1差异无统计学意义（P ＞0．05）。 ACS 患者 sLRP1与 hsCRP 浓度显著正相关（r＝0．713，P ＝0．000），与 MMP－9浓度无相关性。结论sLRP1可能是反映 ACS 炎症状态的一个指标。
목적：관찰관심병환자혈장가용성저밀도지단백수체상관단백1（sLRP1）농도적변화，병분석기여기질금속단백매9（MMP－9）화고민 C 반응단백（hsCRP）농도변화적상관성。방법선취2013년8～10월북경안정의원심내과주원적12례은정형심교통（SAP）、32례급성관맥종합정（ACS），동기관맥조영음성적환자8례위대조조。우개입술전공복검측혈장 sL－RP1、MMP－9화 hsCRP 적농도，비교삼조지간차이。개입술후제일천공복검측환자혈장 sLRP1，병여술전상비교，분석관심병환자 sLRP1여 MMP－9、hsCRP 적상관성。결과술전 ACS 조 sLRP1、MMP－9화 hsCRP 농도현저고우 SAP 조화대조조，차이유통계학의의（균 P ＜0．01），이 SAP 조화대조조비교차이무통계학의의（P ＞0．05）。 ACS 조환자개입술전화술후 sLRP1차이무통계학의의（P ＞0．05）。 ACS 환자 sLRP1여 hsCRP 농도현저정상관（r＝0．713，P ＝0．000），여 MMP－9농도무상관성。결론sLRP1가능시반영 ACS 염증상태적일개지표。
Objective To observe the changes of soluble low density lipoprotein receptor related protein 1(sLRP1) concentra-tion in coronary artery disease and its association with matrix metalloproteases -9 (MMP-9) and C reactive protein (CRP).Methods Patients with stable angina pectoris (SAP,n=12),acute coronary syndrome (ACS,n=32) and control subjects (n=8) from August to October,2013 in Beijing Anzhen Hospital were enrolled in the study .The plasma concentration of sLRP1,MMP-9 and hsCRP was tested by specific ELISA analysis.Differences in these three markers were compared among the three groups .Furthermore,sLRP1 in fasting plasma was detected on the first day after intervention and compared to before intervention ,and explore the correlation between the SL -RP1 and MMP-9、hsCRP.Results The plasma concentration of sLRP1 was increased in patients with ACS when compared to patients with SAP (P <0.01) and the control group (P <0.01).However,no significant difference was found between the SAP group and con -trol group.The concentration of MMP-9 and hsCRP were increased in the ACS group compared to the SAP and control groups .However, there is no significant difference between the SAP and control groups .The concentration of sLRP1 was correlated to hsCRP significantly (P =0.000) but not MMP-9.Conclusion sLRP1 may reflex inflammatory status of patients with acute coronary syndrome .