中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
7期
593-596
,共4页
赵丹%尹春岭%王重利%张晨%张丽丽%张海青
趙丹%尹春嶺%王重利%張晨%張麗麗%張海青
조단%윤춘령%왕중리%장신%장려려%장해청
非小细胞肺癌%细胞角蛋白7%甲状腺转录因子1%新天冬氨酸蛋白酶A%细胞角蛋白5/6%p40%p63%免疫组化
非小細胞肺癌%細胞角蛋白7%甲狀腺轉錄因子1%新天鼕氨痠蛋白酶A%細胞角蛋白5/6%p40%p63%免疫組化
비소세포폐암%세포각단백7%갑상선전록인자1%신천동안산단백매A%세포각단백5/6%p40%p63%면역조화
Nonsmall-cell lung cancer%Cell keratin 7%Thyroid transcription factor-1%Napsin A%Cell keratin 5/6%p40%p63%Immunohistochemistry
目的 探讨肺腺癌及鳞状细胞癌鉴别诊断中有价值的免疫组化指标.方法 选择非小细胞肺癌(NSCLC)病例标本共329例,分析其临床病理特征及免疫组化细胞角蛋白7(CK7)、甲状腺转录因子1(TF-1)、新天冬氨酸蛋白酶A(Napsin A)、细胞角蛋白5/6(CK5/6)、p40、p63表达情况.结果 (1)329例NSCLC标本含肿物切除标本129例,活检标本195例,胸水标本5例.(2)含肺腺癌187例,肺鳞状细胞癌142例.(3)在肺腺癌及鳞状细胞癌鉴别诊断中,CK7、TTF-1、Napsin A、CK5/6、p40、p63在肺腺癌中的阳性率分别为97.9％、87.2％、81.3％、6.4％、3.7％、18.7％,在肺鳞状细胞癌中的阳性率分别为25.4％、11.3％、0、92.3％、95.1％、98.6％.对比两组指标,差异有统计学意义(x2值分别为190.665、187.432、214.542、242.003、274.407、206.818,P均＜0.001).(4)在3个肺腺癌指标中,CK7敏感性最高,Napsin A特异性最高;在3个肺鳞状细胞癌指标中,p63敏感性最高,040特异性最高.结论 CK7、TTF-1、Napsin A、CK5/6、p40、p63可以做为NSCLC鉴别诊断的一组指标.
目的 探討肺腺癌及鱗狀細胞癌鑒彆診斷中有價值的免疫組化指標.方法 選擇非小細胞肺癌(NSCLC)病例標本共329例,分析其臨床病理特徵及免疫組化細胞角蛋白7(CK7)、甲狀腺轉錄因子1(TF-1)、新天鼕氨痠蛋白酶A(Napsin A)、細胞角蛋白5/6(CK5/6)、p40、p63錶達情況.結果 (1)329例NSCLC標本含腫物切除標本129例,活檢標本195例,胸水標本5例.(2)含肺腺癌187例,肺鱗狀細胞癌142例.(3)在肺腺癌及鱗狀細胞癌鑒彆診斷中,CK7、TTF-1、Napsin A、CK5/6、p40、p63在肺腺癌中的暘性率分彆為97.9％、87.2％、81.3％、6.4％、3.7％、18.7％,在肺鱗狀細胞癌中的暘性率分彆為25.4％、11.3％、0、92.3％、95.1％、98.6％.對比兩組指標,差異有統計學意義(x2值分彆為190.665、187.432、214.542、242.003、274.407、206.818,P均＜0.001).(4)在3箇肺腺癌指標中,CK7敏感性最高,Napsin A特異性最高;在3箇肺鱗狀細胞癌指標中,p63敏感性最高,040特異性最高.結論 CK7、TTF-1、Napsin A、CK5/6、p40、p63可以做為NSCLC鑒彆診斷的一組指標.
목적 탐토폐선암급린상세포암감별진단중유개치적면역조화지표.방법 선택비소세포폐암(NSCLC)병례표본공329례,분석기림상병리특정급면역조화세포각단백7(CK7)、갑상선전록인자1(TF-1)、신천동안산단백매A(Napsin A)、세포각단백5/6(CK5/6)、p40、p63표체정황.결과 (1)329례NSCLC표본함종물절제표본129례,활검표본195례,흉수표본5례.(2)함폐선암187례,폐린상세포암142례.(3)재폐선암급린상세포암감별진단중,CK7、TTF-1、Napsin A、CK5/6、p40、p63재폐선암중적양성솔분별위97.9％、87.2％、81.3％、6.4％、3.7％、18.7％,재폐린상세포암중적양성솔분별위25.4％、11.3％、0、92.3％、95.1％、98.6％.대비량조지표,차이유통계학의의(x2치분별위190.665、187.432、214.542、242.003、274.407、206.818,P균＜0.001).(4)재3개폐선암지표중,CK7민감성최고,Napsin A특이성최고;재3개폐린상세포암지표중,p63민감성최고,040특이성최고.결론 CK7、TTF-1、Napsin A、CK5/6、p40、p63가이주위NSCLC감별진단적일조지표.
Objective To study the significant immunohistochemical marker to identify lung adenocarcinoma(ADC) and squamous cell carcinoma(SCC).Methods Three hundred and twenty-nine Choose 329 cases of nonsmall-cell lung cancer (NSCLC) were chosen.Analysis of the clinical and pathological features.The expression of cell keratin 7 (CK7),thyroid transcription factor-1 (TTF-1),Napsin A,CK5/6,p40 and p63 were detected by using immunohistochemistry.Results (1) Among 329 specimens,containing 129 cases of resections,195 cases of biopsies and 5 cases of pleural effusion specimens.(2)In these cases,187 cases were classified to be ADC,142 cases were classified to be SCC.(3) CK7,TTF-1,Napsin A,CK5/6,p40,p63 sensitivity were 97.9％,87.2％,81.3％,6.4％,3.7％,18.7％ in ADC groups,and 25.4％,11.3％,0,92.3％,95.1％,98.6％ in SCC groups,and the differences of two groups were significant statistically (x2 =190.665,187.432,214.542,242.003,274.407,206.818;P＜ 0.001).(4) In the 3 IHC of ADC,CK7 had the highest sensitivity,Napsin A had the highest specificity.In the 3 IHC of SCC,p63 had the highest sensitivity,p40 had the highest specificity.Conclusion CK7,TTF-1,Napsin A,CK5/6,p40 and p63 can be a markable panel of immunohistochemistry in the differential diagnosis of NSCLC.
