中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
7期
613-615
,共3页
张海燕%谭秀革%赵宗敏%张春鹏%陈奕菲%陈建霞%韩涛
張海燕%譚秀革%趙宗敏%張春鵬%陳奕菲%陳建霞%韓濤
장해연%담수혁%조종민%장춘붕%진혁비%진건하%한도
青年人%缺血性脑卒中%同型半胱氨酸%维生素B12%叶酸
青年人%缺血性腦卒中%同型半胱氨痠%維生素B12%葉痠
청년인%결혈성뇌졸중%동형반광안산%유생소B12%협산
The youth%Ischemic stroke%Homocysteinaemia%Vitamin B12%Folic acid
目的 探讨青年缺血性脑卒中患者血同型半胱氨酸(Hcy)、叶酸和维生素B12水平变化及其应用维生素B6、维生素B12和叶酸治疗后的水平变化.方法 选取我院2003年1月至2013年12月住院的青年缺血性脑卒中患者120例作为病例组(干预组60例和非干预组60例),同时选取我院同期年龄相同的无神经系统疾病青年体检者120名作为对照组.检测研究者的血浆Hcy、叶酸、维生素B12浓度.非干预组给予基础治疗,干预组在此基础上给予维生素B6、维生素B12和叶酸治疗.治疗4周后复测血浆Hcy、叶酸和维生素B12水平.结果 与对照组血浆Hcy水平(10.2±3.1)μmmol/L比较,病例组(21.3±4.5)μmmol/L明显升高(t=22.3,P<0.05);干预组与非干预组之间血浆Hcy、叶酸和维生素B12水平差异无统计学意义(P均>0.05).治疗后干预组血浆Hcy水平(10.5±3.0)μmmol/L明显下降,叶酸(6.5±2.8)μg/L和维生素B12水平(450.2±155.6) ng/L)升高(P均<0.05).结论 青年缺血性脑卒中患者血浆Hcy水平升高,通过补充维生素B6、维生素B12和叶酸可降低血浆Hcy水平,有利于青年缺血性脑卒中的转归.
目的 探討青年缺血性腦卒中患者血同型半胱氨痠(Hcy)、葉痠和維生素B12水平變化及其應用維生素B6、維生素B12和葉痠治療後的水平變化.方法 選取我院2003年1月至2013年12月住院的青年缺血性腦卒中患者120例作為病例組(榦預組60例和非榦預組60例),同時選取我院同期年齡相同的無神經繫統疾病青年體檢者120名作為對照組.檢測研究者的血漿Hcy、葉痠、維生素B12濃度.非榦預組給予基礎治療,榦預組在此基礎上給予維生素B6、維生素B12和葉痠治療.治療4週後複測血漿Hcy、葉痠和維生素B12水平.結果 與對照組血漿Hcy水平(10.2±3.1)μmmol/L比較,病例組(21.3±4.5)μmmol/L明顯升高(t=22.3,P<0.05);榦預組與非榦預組之間血漿Hcy、葉痠和維生素B12水平差異無統計學意義(P均>0.05).治療後榦預組血漿Hcy水平(10.5±3.0)μmmol/L明顯下降,葉痠(6.5±2.8)μg/L和維生素B12水平(450.2±155.6) ng/L)升高(P均<0.05).結論 青年缺血性腦卒中患者血漿Hcy水平升高,通過補充維生素B6、維生素B12和葉痠可降低血漿Hcy水平,有利于青年缺血性腦卒中的轉歸.
목적 탐토청년결혈성뇌졸중환자혈동형반광안산(Hcy)、협산화유생소B12수평변화급기응용유생소B6、유생소B12화협산치료후적수평변화.방법 선취아원2003년1월지2013년12월주원적청년결혈성뇌졸중환자120례작위병례조(간예조60례화비간예조60례),동시선취아원동기년령상동적무신경계통질병청년체검자120명작위대조조.검측연구자적혈장Hcy、협산、유생소B12농도.비간예조급여기출치료,간예조재차기출상급여유생소B6、유생소B12화협산치료.치료4주후복측혈장Hcy、협산화유생소B12수평.결과 여대조조혈장Hcy수평(10.2±3.1)μmmol/L비교,병례조(21.3±4.5)μmmol/L명현승고(t=22.3,P<0.05);간예조여비간예조지간혈장Hcy、협산화유생소B12수평차이무통계학의의(P균>0.05).치료후간예조혈장Hcy수평(10.5±3.0)μmmol/L명현하강,협산(6.5±2.8)μg/L화유생소B12수평(450.2±155.6) ng/L)승고(P균<0.05).결론 청년결혈성뇌졸중환자혈장Hcy수평승고,통과보충유생소B6、유생소B12화협산가강저혈장Hcy수평,유리우청년결혈성뇌졸중적전귀.
Objective To explore the variations and prognostic factors of hyperhomocysteinaemia in ischemic cerebral apoplexy for the youth who administrated vitamin B6,vitamin B12 and folic acid at pretherapy and post-treatment.Methods One hundred and twenty cases of young patients with ischemic cerebral apoplexy in the Pinggu Hospital of Capital University from January 2003 to December 2013 as case group(intervention group,60 cases and 60 cases of non-intervention group),while 120 youth volunteers with the same period and age without neurological diseases as a control group.Both groups patients were detected for hyperhomocysteinaemia,folic acid and vitamin B12.The non-intervention group was administrated basic treatment,while the intervention group administrated vitamin B6,vitamin B12 and folic acid on this basis.The hyperhomocysteinaemia,folic acid and vitamin B12 were detected repetitively after four weeks.Results Compared with control group,the hyperhomocysteinaemia in ischemic cerebral apoplexy group for the youth had increased significantly ((10.2 ± 3.1) μmmol/L vs.(21.3 ± 4.5) μmmol/L,P < 0.05).The hyperhomocysteinaemia,folic acid and vitamin B12 had no significant differences between intervention group and non-intervention group (P > 0.05).After replenished vitamin B6,vitamin B12 and folic acid,the hyperhomocysteinaemia had decreased significantly ((10.5 ± 3.0) μmnol/L) in intervention group.Folic acid ((6.5±2.8)μg/L) and vitamin B12(450.2±155.6) ng/L) had increased significantly(P<0.05).Conclusion The hyperhomocysteinaemia increased in ischemic cerebral apoplexy for the youth.It is that hyperhomocysteinaemia decreased by replenished vitamin B6,vitamin B12 and folic acid which make for prognosis in ischemic cerebral apoplexy for the youth.