CAJ | 학술논문

目的：探讨帕罗西汀治疗强迫症患者的临床疗效。方法选取2011年8月至2013年8月收治的符合中国精神障碍分类与诊断标准第3版（CCMD-3）强迫症诊断标准患者100例，按随机数字表法将其分为A组和B两组，各50例。A组患者常规应用帕罗西汀治疗，B组患者应用盐酸氯米帕明治疗。比较两组患者的临床疗效。结果两组患者治疗8周的Yale-Brow强迫量表评分均明显低于治疗前、治疗后4周，呈时间依赖性，差异均有统计学意义（均P＜0.05）；A组患者的总有效率为96.0%，明显高于B组的80.0%，差异有统计学意义（P＜0.05）；A组患者的不良反应发生率为10.0%，明显低于B组的28.0%，差异有统计学意义（P＜0.05）。结论临床对强迫症患者采用帕罗西汀治疗，效果明显，不良反应发生率低，同时还具有用药方便、剂量小等特点。
목적：탐토파라서정치료강박증환자적림상료효。방법선취2011년8월지2013년8월수치적부합중국정신장애분류여진단표준제3판（CCMD-3）강박증진단표준환자100례，안수궤수자표법장기분위A조화B량조，각50례。A조환자상규응용파라서정치료，B조환자응용염산록미파명치료。비교량조환자적림상료효。결과량조환자치료8주적Yale-Brow강박량표평분균명현저우치료전、치료후4주，정시간의뢰성，차이균유통계학의의（균P＜0.05）；A조환자적총유효솔위96.0%，명현고우B조적80.0%，차이유통계학의의（P＜0.05）；A조환자적불량반응발생솔위10.0%，명현저우B조적28.0%，차이유통계학의의（P＜0.05）。결론림상대강박증환자채용파라서정치료，효과명현，불량반응발생솔저，동시환구유용약방편、제량소등특점。
Objective Objective to explore the clinical efficacy of treatment of obsessive-compulsive disorder Pa Rossi Dean.Methods Selected in our hospital from August 2011 to 2013 August,with mental disorders in China Classification and diagnostic criteria of the 3rd Edition(CCMD-3)diagnostic criteria for OCD patients with 100 cases, divided into two groups (group A and B according to the random number table method,50 cases in each group.A group of patients with routine application of Pa Rossi Dean therapy,B group were treated with clomipramine hydro- chloride treatment.Comparison of the clinical efficacy of two groups of patients.Results 8 weeks of Yale-Brow Compulsive Scale score were significantly lower than those before treatment,after treatment of 4 weeks,a time dependent manner,differences were statisticaly significant(P<0.05);patients in group a total efficiency was 96.0% and was significantly higher than that in group B (80.0%),the difference is statisticaly significant(P<0.05)in the treatment of patients in the two groups.The adverse reactions of patients in group A were occurrence rate was 10.0%, significantly lower than group B(28.0%),the difference was statisticaly significant(P<0.05).Conclusion On the clinical manifestations of obsessive-compulsive disorder patients with antidepressant paroxetine in the treatment,the effect is obvious,the low incidence of adverse reactions.At the same time,also has convenient usage,smal dosage.