国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2015年
8期
619-621
,共3页
头颈部肿瘤%血管生成抑制剂%血管内皮生长因子 A
頭頸部腫瘤%血管生成抑製劑%血管內皮生長因子 A
두경부종류%혈관생성억제제%혈관내피생장인자 A
Head and neck neoplasms%Angiogenesis inhibitors%Vascular endothelial growth factor A
目前对于复发或转移头颈部鳞状细胞癌(HNSCC)以姑息性化疗及 EGFR 靶向治疗为主,肿瘤血管的形成是肿瘤生长和远处转移的关键因素,因此,促进血管生成的因子及其受体成为靶向治疗的靶点,目前抗血管生成药物主要通过阻断 VEGF-VEGF 受体(VEGFR)通路,其在治疗 HNSCC 的临床试验中取得一定效果,为治疗 HNSCC 提供更多选择。
目前對于複髮或轉移頭頸部鱗狀細胞癌(HNSCC)以姑息性化療及 EGFR 靶嚮治療為主,腫瘤血管的形成是腫瘤生長和遠處轉移的關鍵因素,因此,促進血管生成的因子及其受體成為靶嚮治療的靶點,目前抗血管生成藥物主要通過阻斷 VEGF-VEGF 受體(VEGFR)通路,其在治療 HNSCC 的臨床試驗中取得一定效果,為治療 HNSCC 提供更多選擇。
목전대우복발혹전이두경부린상세포암(HNSCC)이고식성화료급 EGFR 파향치료위주,종류혈관적형성시종류생장화원처전이적관건인소,인차,촉진혈관생성적인자급기수체성위파향치료적파점,목전항혈관생성약물주요통과조단 VEGF-VEGF 수체(VEGFR)통로,기재치료 HNSCC 적림상시험중취득일정효과,위치료 HNSCC 제공경다선택。
Current treatment strategies for recurrent or metastatic head and neck squamous cell carcino-ma(HNSCC)include palliative chemotherapy and anti-EGFR targeted agents.Angiogenesis is crucial both for the growth of a primary tumor and the development of distant metastasis.Therefore,the angiogenesis factors and their receptors become the targets of therapeutic agents.Current anti-angiogenesis drugs achieve the purpose of treatment mainly by blocking VEGF-VEGFR pathways.And it gets certain effects in clinical trials for the treat-ment of HNSCC.Anti-angiogenesis therapy will provide more choices for treating HNSCC.