中国药物经济学
中國藥物經濟學
중국약물경제학
CHINA JOURNAL OF PHARMACEUTICAL ECONOMICS
2015年
8期
8-11
,共4页
高磷血症%碳酸镧%碳酸钙%安慰剂%终末期肾病
高燐血癥%碳痠鑭%碳痠鈣%安慰劑%終末期腎病
고린혈증%탄산란%탄산개%안위제%종말기신병
Hyperphosphatemia%Lanthanum carbonate%Calcium carbonate%Placebo%End-stage renal disease
目的：探讨碳酸镧治疗慢性肾衰竭并发高磷血症患者的疗效。方法以碳酸镧（lanthanum carbonate）、高磷血症（hyperphosphatemia）、安慰剂（placebo）、碳酸钙（calcium carbonate）、终末期肾病（end-stage renal disease）等为关键字，检索中国期刊全文数据库、中文科技期刊数据库、万方数据知识服务平台、Web of Science、PubMed等数据库，对文献的质量评价后进行Meta分析。结果共纳入10篇，经Meta分析结果显示，对于治疗后血磷水平，WMD=－0.60，95%CI：－0.75～－0.45，碳酸镧与安慰剂在控制血磷水平上差异有统计学意义；对于治疗后血钙水平，WMD=－0.01，95%CI：－0.07～0.05，碳酸镧与安慰剂在控制血钙水平上差异无统计学意义；对于治疗后血PTH水平，WMD=－29.75，95%CI：－39.22～－20.28，说明碳酸镧与安慰剂在控制血PTH水平上差异有统计学意义。对于治疗后血磷水平，WMD=－0.41，95%CI：－0.48～－0.34，碳酸镧与碳酸钙在控制血磷水平上差异有统计学意义；对于治疗后血钙水平，WMD=－0.19，95%CI：－0.25～－0.13，碳酸镧与碳酸钙在控制血钙水平上有统计学意义；对于治疗后血PTH水平，WMD=－174.66，95%CI：－198.86～－150.46，碳酸镧与碳酸钙在控制血 PTH 水平上差异有统计学意义。结论碳酸镧可明显降低慢性肾衰竭并发高磷血症患者的血磷和PTH，对血钙无明显影响，在有效性上优于碳酸钙。
目的：探討碳痠鑭治療慢性腎衰竭併髮高燐血癥患者的療效。方法以碳痠鑭（lanthanum carbonate）、高燐血癥（hyperphosphatemia）、安慰劑（placebo）、碳痠鈣（calcium carbonate）、終末期腎病（end-stage renal disease）等為關鍵字，檢索中國期刊全文數據庫、中文科技期刊數據庫、萬方數據知識服務平檯、Web of Science、PubMed等數據庫，對文獻的質量評價後進行Meta分析。結果共納入10篇，經Meta分析結果顯示，對于治療後血燐水平，WMD=－0.60，95%CI：－0.75～－0.45，碳痠鑭與安慰劑在控製血燐水平上差異有統計學意義；對于治療後血鈣水平，WMD=－0.01，95%CI：－0.07～0.05，碳痠鑭與安慰劑在控製血鈣水平上差異無統計學意義；對于治療後血PTH水平，WMD=－29.75，95%CI：－39.22～－20.28，說明碳痠鑭與安慰劑在控製血PTH水平上差異有統計學意義。對于治療後血燐水平，WMD=－0.41，95%CI：－0.48～－0.34，碳痠鑭與碳痠鈣在控製血燐水平上差異有統計學意義；對于治療後血鈣水平，WMD=－0.19，95%CI：－0.25～－0.13，碳痠鑭與碳痠鈣在控製血鈣水平上有統計學意義；對于治療後血PTH水平，WMD=－174.66，95%CI：－198.86～－150.46，碳痠鑭與碳痠鈣在控製血 PTH 水平上差異有統計學意義。結論碳痠鑭可明顯降低慢性腎衰竭併髮高燐血癥患者的血燐和PTH，對血鈣無明顯影響，在有效性上優于碳痠鈣。
목적：탐토탄산란치료만성신쇠갈병발고린혈증환자적료효。방법이탄산란（lanthanum carbonate）、고린혈증（hyperphosphatemia）、안위제（placebo）、탄산개（calcium carbonate）、종말기신병（end-stage renal disease）등위관건자，검색중국기간전문수거고、중문과기기간수거고、만방수거지식복무평태、Web of Science、PubMed등수거고，대문헌적질량평개후진행Meta분석。결과공납입10편，경Meta분석결과현시，대우치료후혈린수평，WMD=－0.60，95%CI：－0.75～－0.45，탄산란여안위제재공제혈린수평상차이유통계학의의；대우치료후혈개수평，WMD=－0.01，95%CI：－0.07～0.05，탄산란여안위제재공제혈개수평상차이무통계학의의；대우치료후혈PTH수평，WMD=－29.75，95%CI：－39.22～－20.28，설명탄산란여안위제재공제혈PTH수평상차이유통계학의의。대우치료후혈린수평，WMD=－0.41，95%CI：－0.48～－0.34，탄산란여탄산개재공제혈린수평상차이유통계학의의；대우치료후혈개수평，WMD=－0.19，95%CI：－0.25～－0.13，탄산란여탄산개재공제혈개수평상유통계학의의；대우치료후혈PTH수평，WMD=－174.66，95%CI：－198.86～－150.46，탄산란여탄산개재공제혈 PTH 수평상차이유통계학의의。결론탄산란가명현강저만성신쇠갈병발고린혈증환자적혈린화PTH，대혈개무명현영향，재유효성상우우탄산개。
Objective To investigate the efect of lanthanum carbonate treating chronic renal failure with high phosph- orus.Methods Lanthanum carbonate,high phosphorus hyperlipidemia hyperphosphatemia placebo,calcium carbonate, final end-stage renal disease as key words,are retrievaled in China journal ful text database,Chinese science technology periodical database,Wanfang Data of Knowledge service platform,web of science,PubMed database,after the evaluation of the quality of the literature for meta analysis.Results A total of 10 papers, by the meta analysis results showed that,after the treatment,in serum phosphorus level WMD=-0.60,95%CI:-0.75 to-0.45,the difference of lanthanum carbonate comparing with placebo in the control of serum phosphorus level have statistical significance;for blood calcium levels after treatment,WMD=-0.01,95%CI:-0.07 to 0.05,the diference of lanthanum carbonate comparing with placebo in controling serum calcium levels were not statisticaly significant;for PTH levels after treatment,WMD=-29.75,95%CI:-39.22 to-20.28,the difference of lanthanum carbonate comparing with placebo in the control of serum PTH level was statisticaly significant;For the serum phosphorus level after treatment, WMD=-0.41,95%CI:-0.48 to-0.34,the difer- rence of lanthanum c arbonate comparing with calcium are obviously different, after treatment for blood calcium levels, WMD=-0.19,95%CI:-0.25 to-0.13,the difference of lanthanum carbonate comparing with calcium,there were significant differences,for the blood PTH level after treatment,WMD=-174.66,95%CI:-198.86 to-150.46,the diference of lanthanum carbonate comparing with calcium,there were significant differences.Conclusion Lanthanum carbonate can significantly reduce serum phosphorus and PTH,had no significant efect on serum calcium.The efectiveness of Lanthanum carbonate is better than that of calcium carbonate.
