CAJ | 학술논문

海藻酸钙胶囊膜由于具有制备过程温和环保、材料生物相容性优良等优点，广泛应用于生物医药等领域。薄壁结构的胶囊膜可减小跨膜传质阻力，加速囊膜内外物质的交换，因而备受学术界和工业界的广泛关注。近年来，具有超薄壁结构的海藻酸钙胶囊膜的制备与改性成为一个研究热点。本文综述了超薄壁结构海藻酸钙胶囊膜的制备方法及其功能化的研究新进展，重点介绍了利用共挤出毛细管装置制备超薄壁结构的海藻酸钙胶囊膜、利用精蛋白吸附与仿生硅化技术对超薄壁结构海藻酸钙胶囊膜的有机/无机杂化处理，以及利用复合纳米响应性凝胶颗粒的方法和接枝响应性聚合物高分子的方法实现超薄壁结构海藻酸钙胶囊膜的功能化改性等方面的研究现状。
해조산개효낭막유우구유제비과정온화배보、재료생물상용성우량등우점，엄범응용우생물의약등영역。박벽결구적효낭막가감소과막전질조력，가속낭막내외물질적교환，인이비수학술계화공업계적엄범관주。근년래，구유초박벽결구적해조산개효낭막적제비여개성성위일개연구열점。본문종술료초박벽결구해조산개효낭막적제비방법급기공능화적연구신진전，중점개소료이용공제출모세관장치제비초박벽결구적해조산개효낭막、이용정단백흡부여방생규화기술대초박벽결구해조산개효낭막적유궤/무궤잡화처리，이급이용복합납미향응성응효과립적방법화접지향응성취합물고분자적방법실현초박벽결구해조산개효낭막적공능화개성등방면적연구현상。
Calcium alginate (Ca-alginate) capsule membranes are widely used in biological and medical fields due to their notable advantages such as good biocompatibility, and mild gelation conditions. Thin capsule membranes are desired to reduce the resistance to the mass transfer across the membranes, and to accelerate the exchange of solutes between the internal space of the capsule and the external environment. Therefore, fabrication and functionalization of Ca-alginate capsules with ultrathin membranes have attracted much attention recently. This paper reviews recent progress in fabrication and functionalization of Ca-alginate capsules with ultrathin membranes, and the controllable fabrication of Ca-alginate capsules with ultrathin membranesvia a co-extrusion approach, organic/inorganic hybrid processingvia adsorption of protamine molecules and biosilicification as well as functional modification of the Ca-alginate capsules with ultrathin membranes are highlighted. The thicknesses of the resultant Ca-alginate capsule membranes range from 0.6 to 150 μm, and the permeability performance of the capsule membranes could be controllably adjusted. The strategy reported in this paper provides a novel approach to fabricate novel structures of capsule membranes for various applications, particularly as a new tool for screening microorganism survival and growth in three-dimensional environments. Protamine is used to inspire andtemplate silica formation onto the surfaces of the Ca-alginate capsules, which provides a facile and efficient method to prepare the organic/inorganic hybrid capsules with ultrathin membranes. The Ca-alginate/ protamine/silica capsules efficiently inhibit the swelling of Ca-alginate capsules, and thus are promising carriers for encapsulation of cells and enzymes. In addition, Ca-alginate capsules membranes blended with poly(N-isopropylacrylamide) (PNIPAM) nanogels exhibit desirable thermo-responsive gating characteristics. pH-Responsive switching functions can be endowed by the electrostatic interactions between Ca-alginate networks and protamine molecules, or by the swelling/shrinking behaviors of the grafted poly(methacrylic acid) (PMAA) brushes on the capsule membranes. These functional capsules with ultrathin membranes have many potential applications in various fields such as enzyme catalytic reactions, immobilizations of cells and foods, and controlled release of chemicals.