中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2015年
7期
611-614
,共4页
潘兴强%马瑞%方挺%许国章
潘興彊%馬瑞%方挺%許國章
반흥강%마서%방정%허국장
水痘疫苗%接种%发病率%水痘突破病例发生率
水痘疫苗%接種%髮病率%水痘突破病例髮生率
수두역묘%접충%발병솔%수두돌파병례발생솔
Chickenpox vaccine%Vaccination%Incidence%Varicella breakthrough infection
目的:分析接种1剂次水痘疫苗的儿童水痘突破病例发生率和疫苗效果。方法选取浙江省宁波市鄞州区、宁海县和余姚市为水痘监测点,以监测点2007—2010年出生的符合纳入标准的本地儿童为研究对象,共57180名。通过《宁波市免疫规划信息系统》和《中国疾病预防控制信息系统》收集其在2008—2013年期间水痘疫苗的接种和水痘的发病等资料,计算各出生队列的水痘突破病例发生率和疫苗效果,分别描述2008—2013年间2007—2010年4个出生队列儿童各项指标的变化情况,并分别比较4个出生队列中,接种和未接种疫苗的儿童水痘累积发病率的差异。结果2008—2013年间,2007—2010年4个出生队列儿童1剂次水痘疫苗的接种率为96.74%(55317/57180);水痘累计发病率为0.56%(321/57180);水痘突破病例总发生率为0.44%(244/55317),2007—2010年4个队列分别为0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)和0.09%(12/13101),且均随时间增加呈上升趋势,其中出生于2007年的儿童突破病例发生率增长最快,从2008年的0.04%(6/14928)增加到了2013年的0.32%(48/14834);2007—2010年各出生队列儿童中,接种了1剂次水痘疫苗的累积发病率分别为0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)和0.09%(12/13101),均低于未接种的累积发病率[发病率分别为:6.25%(37/592)、3.52%(15/426)、3.69%(17/461)和2.08%(8/384)](χ2值分别为130.27、74.11、162.80、100.01,P值均<0.001)。水痘疫苗效果为89.33%(95%CI:86.7%~92.1%),2007—2010年4个出生队列分别为84.78%(95%CI:77.94%~89.50%)、86.82%(95%CI:77.82%~92.95%)、93.99%(95%CI:89.27%~96.81%)和95.60%(95%CI:89.18%~98.21%),且均随时间增加呈下降趋势,其中出生于2009年的儿童接种的疫苗效果下降最快,从2010年的98.86%下降到了2013年的66.83%。结论儿童接种1剂次水痘疫苗后疫苗效果较好,但水痘突破病例发生率随接种时间的延长呈逐年上升趋势,疫苗效果呈下降趋势。
目的:分析接種1劑次水痘疫苗的兒童水痘突破病例髮生率和疫苗效果。方法選取浙江省寧波市鄞州區、寧海縣和餘姚市為水痘鑑測點,以鑑測點2007—2010年齣生的符閤納入標準的本地兒童為研究對象,共57180名。通過《寧波市免疫規劃信息繫統》和《中國疾病預防控製信息繫統》收集其在2008—2013年期間水痘疫苗的接種和水痘的髮病等資料,計算各齣生隊列的水痘突破病例髮生率和疫苗效果,分彆描述2008—2013年間2007—2010年4箇齣生隊列兒童各項指標的變化情況,併分彆比較4箇齣生隊列中,接種和未接種疫苗的兒童水痘纍積髮病率的差異。結果2008—2013年間,2007—2010年4箇齣生隊列兒童1劑次水痘疫苗的接種率為96.74%(55317/57180);水痘纍計髮病率為0.56%(321/57180);水痘突破病例總髮生率為0.44%(244/55317),2007—2010年4箇隊列分彆為0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)和0.09%(12/13101),且均隨時間增加呈上升趨勢,其中齣生于2007年的兒童突破病例髮生率增長最快,從2008年的0.04%(6/14928)增加到瞭2013年的0.32%(48/14834);2007—2010年各齣生隊列兒童中,接種瞭1劑次水痘疫苗的纍積髮病率分彆為0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)和0.09%(12/13101),均低于未接種的纍積髮病率[髮病率分彆為:6.25%(37/592)、3.52%(15/426)、3.69%(17/461)和2.08%(8/384)](χ2值分彆為130.27、74.11、162.80、100.01,P值均<0.001)。水痘疫苗效果為89.33%(95%CI:86.7%~92.1%),2007—2010年4箇齣生隊列分彆為84.78%(95%CI:77.94%~89.50%)、86.82%(95%CI:77.82%~92.95%)、93.99%(95%CI:89.27%~96.81%)和95.60%(95%CI:89.18%~98.21%),且均隨時間增加呈下降趨勢,其中齣生于2009年的兒童接種的疫苗效果下降最快,從2010年的98.86%下降到瞭2013年的66.83%。結論兒童接種1劑次水痘疫苗後疫苗效果較好,但水痘突破病例髮生率隨接種時間的延長呈逐年上升趨勢,疫苗效果呈下降趨勢。
목적:분석접충1제차수두역묘적인동수두돌파병례발생솔화역묘효과。방법선취절강성저파시은주구、저해현화여요시위수두감측점,이감측점2007—2010년출생적부합납입표준적본지인동위연구대상,공57180명。통과《저파시면역규화신식계통》화《중국질병예방공제신식계통》수집기재2008—2013년기간수두역묘적접충화수두적발병등자료,계산각출생대렬적수두돌파병례발생솔화역묘효과,분별묘술2008—2013년간2007—2010년4개출생대렬인동각항지표적변화정황,병분별비교4개출생대렬중,접충화미접충역묘적인동수두루적발병솔적차이。결과2008—2013년간,2007—2010년4개출생대렬인동1제차수두역묘적접충솔위96.74%(55317/57180);수두루계발병솔위0.56%(321/57180);수두돌파병례총발생솔위0.44%(244/55317),2007—2010년4개대렬분별위0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)화0.09%(12/13101),차균수시간증가정상승추세,기중출생우2007년적인동돌파병례발생솔증장최쾌,종2008년적0.04%(6/14928)증가도료2013년적0.32%(48/14834);2007—2010년각출생대렬인동중,접충료1제차수두역묘적루적발병솔분별위0.95%(142/14928)、0.44%(61/13855)、0.22%(29/13433)화0.09%(12/13101),균저우미접충적루적발병솔[발병솔분별위:6.25%(37/592)、3.52%(15/426)、3.69%(17/461)화2.08%(8/384)](χ2치분별위130.27、74.11、162.80、100.01,P치균<0.001)。수두역묘효과위89.33%(95%CI:86.7%~92.1%),2007—2010년4개출생대렬분별위84.78%(95%CI:77.94%~89.50%)、86.82%(95%CI:77.82%~92.95%)、93.99%(95%CI:89.27%~96.81%)화95.60%(95%CI:89.18%~98.21%),차균수시간증가정하강추세,기중출생우2009년적인동접충적역묘효과하강최쾌,종2010년적98.86%하강도료2013년적66.83%。결론인동접충1제차수두역묘후역묘효과교호,단수두돌파병례발생솔수접충시간적연장정축년상승추세,역묘효과정하강추세。
Objective To evaluate the breakthrough varicella infection rate and varicella vaccine effectiveness(VE) among children who received 1-dose varicella vaccine. Methods A total of 57 180 subjects for the consecutive 4-year birth cohorts were selected from the local children born between 2007 and 2010 in Yinzhou District, Ninghai County and Yuyao City.And they were followed up for varicella from 2008 to 2013. The recipients of the vaccinations were identified through Ningbo Immunization Information System and data on breakthrough infections among the recipients were collected by using China Information System for Disease Control and Prevention. The breakthrough varicella rate and the VE were calculated and the trends of them were described from 2008 to 2013 among 4-year birth cohorts.The cumulative incidence of varicella was compared between vaccinated and unvaccinated children among the consecutive 4-year birth cohorts. Results The rate of varicella vaccine coverage, vaccine cumulative incidence among the cohorts was 96.74%(55 317/57 180)and 0.56%(321/57 180). The breakthrough varicella infection for 4-year birth cohorts was 0.44%(244/55 317), and for each birth cohort was 0.95%(142/14 928),0.44%(61/13 855), 0.22%(29/13 433)and 0.09%(12/13 101), respectively. It was on the rise from 2008 to 2013 and the 2007 birth cohort of it increased fastest from 0.04%(6/14 928)in 2007 to 0.32%(48/14 834)in 2013.The vaccine cumulative incidence of these who vaccinated 1-dose varicella(the breakthrough varicella infection) was lower than these who were unvaccinated(the incidence:6.25%(37/592),3.52%(15/426),3.69%(17/461) and 2.08%(8/384))by each birth cohort(χ2=130.27,P<0.001 for 2007 birth cohort;χ2=74.11,P<0.001 for 2008 birth cohort;χ2=162.80,P<0.001 for 2009 birth cohort;χ2=100.01,P<0.001 for 2010 birth cohort) .The vaccine effectiveness for 4-year birth cohorts was 89.33%(95%CI:86.7%-92.1%) and for each birth corhort was 84.78%(95%CI:77.94%-89.50%),86.82%(95%CI:77.82%-92.95%),93.99%(95%CI:89.27%-96.81%)and 95.60%(95%CI:89.18%-98.21%), respectively. The effectiveness of each birth cohort declinedgradually from 2008 to 2013 and the 2009 birth cohort of it decreased fastest from 98.86%in 2010 to 66.83% in 2013. Conclusions The 1-dose varicella vaccine effectiveness was good, but breakthrough varicella infection rate was on the rise with time and the VE declined gradually from 2008 to 2013.