CAJ | 학술논문

男性乳腺癌（MBC）发病罕见，其发病机制和生物学特性尚未明了。目前认为乳腺癌易感基因（BRCA）1、BRCA2，细胞周期检测点激酶2（CHEK2）以及乳腺癌易感基因相关蛋白基因2（PALB2）与男性乳腺癌发病关系密切。而乳腺癌易感基因相互作用蛋白1基因（BRIP1）与男性乳腺癌发病机制尚存争议。
남성유선암（MBC）발병한견，기발병궤제화생물학특성상미명료。목전인위유선암역감기인（BRCA）1、BRCA2，세포주기검측점격매2（CHEK2）이급유선암역감기인상관단백기인2（PALB2）여남성유선암발병관계밀절。이유선암역감기인상호작용단백1기인（BRIP1）여남성유선암발병궤제상존쟁의。
Male breast cancer (MBC)is one of rare malignant carcinomas,of which the pathogenesis and biological characteristics remain elusive.Recently,it has been reported that breast cancer susceptibility gene (BRCA)1 ,BRCA2,checkpoint kinase 2 (CHEK2)and partner and localizer of BRCA2 (PALB2)play important roles in the pathogenesis of MBC.Whereas the relationship between BRCA1 -interacting protein 1 (BRIP1 )and MBC is still controversial.