CAJ | 학술논문

目的：探讨生命早期经历饥荒对成年后静息心率（RHR）增快的影响。方法在2006年6月至2007年10月参加体检的开滦集团在职及离退休职工中，选取1956年10月1日至1964年9月30日出生于河北省且符合纳入排除标准的18619名体检者作为调查对象。收集基本信息、吸烟饮酒情况、RHR及体检结果。将出生于1959年10月1日至1961年9月30日的调查对象定义为饥荒暴露组（3190名），出生于1958年10月1日至1959年9月30日和1961年10月1日至1962年9月30日的调查对象定义为饥荒半暴露组（3851名），出生于1956年10月1日至1958年9月30日和1962年10月1日至1964年9月30日的调查对象定义对照组（11578名），比较3组间RHR的差异，采用多因素logistic回归模型分析生命早期经历饥荒对RHR增快的影响。结果饥荒暴露组及饥荒半暴露组的RHR分别为（74.34±9.71）和（74.41±9.48）次/min，均高于对照组[（73.90±9.45）次/min]，差异均有统计学意义（P值分别为0.003和0.020）。多因素logistic回归模型分析显示，在对性别、年龄及体检等指标进行调整后，总人群中，生命早期经历饥荒增加了其成年后RHR增快的风险，OR（95%CI）值为1.10（1.01～1.21）；在男性人群中，生命早期经历饥荒同样增加了其成年后RHR增快的风险，OR（95%CI）值为1.15(1.04～1.28)；女性人群中，两者之间的关联无统计学意义，OR（95%CI）值为0.92(0.74～1.14)。结论生命早期经历饥荒增加了成年后RHR增快的风险，这种趋势主要存在于男性人群中。
목적：탐토생명조기경력기황대성년후정식심솔（RHR）증쾌적영향。방법재2006년6월지2007년10월삼가체검적개란집단재직급리퇴휴직공중，선취1956년10월1일지1964년9월30일출생우하북성차부합납입배제표준적18619명체검자작위조사대상。수집기본신식、흡연음주정황、RHR급체검결과。장출생우1959년10월1일지1961년9월30일적조사대상정의위기황폭로조（3190명），출생우1958년10월1일지1959년9월30일화1961년10월1일지1962년9월30일적조사대상정의위기황반폭로조（3851명），출생우1956년10월1일지1958년9월30일화1962년10월1일지1964년9월30일적조사대상정의대조조（11578명），비교3조간RHR적차이，채용다인소logistic회귀모형분석생명조기경력기황대RHR증쾌적영향。결과기황폭로조급기황반폭로조적RHR분별위（74.34±9.71）화（74.41±9.48）차/min，균고우대조조[（73.90±9.45）차/min]，차이균유통계학의의（P치분별위0.003화0.020）。다인소logistic회귀모형분석현시，재대성별、년령급체검등지표진행조정후，총인군중，생명조기경력기황증가료기성년후RHR증쾌적풍험，OR（95%CI）치위1.10（1.01～1.21）；재남성인군중，생명조기경력기황동양증가료기성년후RHR증쾌적풍험，OR（95%CI）치위1.15(1.04～1.28)；녀성인군중，량자지간적관련무통계학의의，OR（95%CI）치위0.92(0.74～1.14)。결론생명조기경력기황증가료성년후RHR증쾌적풍험，저충추세주요존재우남성인군중。
Objective To investigate the association between exposure to the famine during early life and elevated resting heart rate(RHR)in adulthood. Method From June 2006 to October 2007, the employees of kailuan group who took part in the health examination were selected. Of those, 18 619 cases who was born during October 1 ,1956 to September 30,1964 in Hebei province were finally included in the analysis based on the inclusion and exclusion criteria. All the subjects were received questionnaire survey, smoking and drinking, physical examination, Lab examination and the measurement of RHR. The subjects of famine exposure group(3 190 cases) were born from October 1 ,1959 to September 30, 1961,semi?exposure group( 3 851 cases) were born from October 1,1958 to September 30, 1959 and from October 1, 1961 to September 30, 1962 ,control group(11 578 cases) were born from October 1, 1956 to September 30, 1958 and from October 1, 1962 to September 30, 1964. The RHR and the detection rate of elevated RHR were compared among the three groups. The Multivariate logistic regression model was used to analyze the association between of exposure to famine during early life and elevated RHR in adulthood. Results The RHR level was higher in famine exposure group and semi?exposed group than control group, which were (74.34 ± 9.71),(74.41 ± 9.48)and(73.90 ± 9.45)beat per minute(bpm)(P values were 0.003 and 0.020, respectively).In all of the subjects. The results of multivariate logistic regression showed that exposure of famine during early life increased the risk of elevated RHR in adulthood after adjustment for age,gender and other confounders (OR=1.10, 95%CI:1.01-1.21). In men, exposure of famine during early life also increased the risk of elevated RHR in adulthood(OR=1.15, 95%CI:1.04-1.28);In women, there was no association between the famine exposure and elevated RHR (OR=0.92,95%CI:0.74-1.14). Conclusion Exposure of famine during early life increases the risk of elevated RHR in adulthood. This negative effect existed mainly in the male.