CAJ | 학술논문

目的：探讨病因不明新生儿惊厥的临床特征及转归。方法总结12例病因不明的新生儿惊厥病例的临床特征及随访结果。结果12例患儿均为足月儿，男7例，女5例；惊厥发作以微小型发作为主；2例住院期动态脑电图示间断低电压改变，10例正常；12例均复查动态脑电图，3例出现爆发棘慢波，9例正常；12例住院期颅部MRI均正常，4例复查颅部MRI未见异常；3例随访中诊断为癫痫，其中1例合并发育迟缓，遗传代谢病筛查诊断为甲基丙二酸血症；6例出院后未再抽搐，3例出院10周内未特殊治疗抽搐停止，目前均生长发育良好。结论病因不明新生儿惊厥的潜在原因可能为癫痫、某种遗传代谢病或良性特发性新生儿惊厥等，应加强随访，追踪观察，及时诊断，积极治疗。
목적：탐토병인불명신생인량궐적림상특정급전귀。방법총결12례병인불명적신생인량궐병례적림상특정급수방결과。결과12례환인균위족월인，남7례，녀5례；량궐발작이미소형발작위주；2례주원기동태뇌전도시간단저전압개변，10례정상；12례균복사동태뇌전도，3례출현폭발극만파，9례정상；12례주원기로부MRI균정상，4례복사로부MRI미견이상；3례수방중진단위전간，기중1례합병발육지완，유전대사병사사진단위갑기병이산혈증；6례출원후미재추휵，3례출원10주내미특수치료추휵정지，목전균생장발육량호。결론병인불명신생인량궐적잠재원인가능위전간、모충유전대사병혹량성특발성신생인량궐등，응가강수방，추종관찰，급시진단，적겁치료。
ObjectiveTo evaluate the clinical manifestations and follow-up of the neonatal convulsion with unknown reasons.MethodsThe clinical manifestations and the outcome of 12 patients with the agnogenic neonatal convulsion have been summarized.ResultsAll the patients were full term infants,7 boys,5 girls;The behaviour of convulsion was subtle;The AEEG of 2 patients show interrupted low voltage,the other 10 patients' were normal;The AEEG of all 12 patients were reexamined,3 patients show spike and slow wave,the other 9 patients' were normal;The MRI of 12 patients were normal during in hospital;4 patients' MRI were reexamined,normal;3 patients were diagnosed as epilepsy,One has growth retardation,who was diagnosised methylmalon academia;6 patients had no convulsion after treatment in hospital,At present they developed normally,The convulsion of 3 patients discontinued in 10 weeks after discharge,They had a good follow-up till now.ConclusionBoth epilepsy and benign idiopathic neonatal convulsions was the potential origin of neonatal convulsion with unknown reasons. It is important to follow-up and find reason for the neonatal convulsion with unknown reasons.