CAJ | 학술논문

目的：探讨甘氨双唑钠（CMNa）对鼻咽癌放疗增敏作用的临床疗效和安全性。方法检索中国生物医学文献数据库、中国期刊全文数据库（CNKI）、万方医药期刊全文数据库、中文科技期刊数据库、PubMed 和 Cochrane 图书馆，收集放疗联合 CMNa 与单纯放疗治疗鼻咽癌的临床随机对照研究（RCT）。根据纳入排除标准筛选文献，对符合条件的 RCT 由两位研究者独立进行资料提取和质量评价后，采用 Cochrane 协作网提供的 RevMan 5．2进行 Meta 分析。结果放疗联合 CMNa 对中晚期鼻咽癌原位灶增敏治疗 CR 率是单纯放疗的1．41倍，RR ＝1．41，95％CI 为1．30～1．52，Z ＝8．20，P ＝0．00；颈淋巴结转移灶 CR 率是单纯放疗的1．45倍，RR ＝1．45，95％CI 为1．30～1．62，Z ＝6．50，P ＝0．00。皮肤（RR ＝0．97，95％CI 为0．87～1．08，Z ＝0．57，P ＝0．57）、黏膜（RR ＝1．03，95％CI 为0．93～1．15，Z ＝0．65，P ＝0．52）、白细胞减少（RR ＝0．84，95％CI 为0．56～1．25，Z ＝0．87，P ＝0．38）不良反应两组差异均无统计学意义。结论放疗联合 CMNa 治疗中晚期鼻咽癌无论是原发灶还是颈淋巴转移灶均较单纯放疗效果好，而不良反应的发生率并无差异。
목적：탐토감안쌍서납（CMNa）대비인암방료증민작용적림상료효화안전성。방법검색중국생물의학문헌수거고、중국기간전문수거고（CNKI）、만방의약기간전문수거고、중문과기기간수거고、PubMed 화 Cochrane 도서관，수집방료연합 CMNa 여단순방료치료비인암적림상수궤대조연구（RCT）。근거납입배제표준사선문헌，대부합조건적 RCT 유량위연구자독립진행자료제취화질량평개후，채용 Cochrane 협작망제공적 RevMan 5．2진행 Meta 분석。결과방료연합 CMNa 대중만기비인암원위조증민치료 CR 솔시단순방료적1．41배，RR ＝1．41，95％CI 위1．30～1．52，Z ＝8．20，P ＝0．00；경림파결전이조 CR 솔시단순방료적1．45배，RR ＝1．45，95％CI 위1．30～1．62，Z ＝6．50，P ＝0．00。피부（RR ＝0．97，95％CI 위0．87～1．08，Z ＝0．57，P ＝0．57）、점막（RR ＝1．03，95％CI 위0．93～1．15，Z ＝0．65，P ＝0．52）、백세포감소（RR ＝0．84，95％CI 위0．56～1．25，Z ＝0．87，P ＝0．38）불량반응량조차이균무통계학의의。결론방료연합 CMNa 치료중만기비인암무론시원발조환시경림파전이조균교단순방료효과호，이불량반응적발생솔병무차이。
Objective To assess the efficacy and safety of radiotherapy combined with sodium glyci-didazole (CMNa)in treating nasopharyngeal carcinoma by conducting a Meta-analysis.Methods Randomized clinical controlled studies (RCTs)of radiotherapy plus CMNa versus radiotherapy alone in the treatment of nasopharyngeal carcinoma were retrieved from China Biology Medicine disc,China National Knowledge Infrastruc-ture,digital journal of Wanfang Data,China Science and Technology Journal Database,PubMed and Cochrane Library.According to the inclusion and exclusion criteria,data extraction and quality assessment were done by two researchers independently,and clinically important measures were selected.Outcomes were pooled with Rev-Man 5.2.Results The rate of complete remission (CR)in the radiotherapy combined CMNa group was better than that in the radiotherapy alone group in 1 .41 multiple to primary lesion,RR =1 .41 ,95%CI:1 .30-1 .52, Z =8.20,P =0.00.To lymphonodi cervicales metastasis,the rate of CR in the radiotherapy combined CMNa group was better than that in the radiotherapy alone group in 1 .45 multiple,RR =1 .45,95%CI:1 .30-1 .62, Z =6.50,P =0.00.There were no significant differences in the incidence rates of adverse reactions of skin (RR =0.97,95%CI:0.87-1 .08,Z =0.57,P =0.57 ),mucosa (RR =1 .03,95%CI:0.93-1 .15,Z =0.65, P =0.52 )and decrease in white blood cells (RR =0.84,95% CI:0.56-1 .25,Z =0.87,P =0.38). Conclusion In the treatments of nasopharyngeal carcinoma,the rates of CR of primary lesion and lymphonodi cervicales metastasis in radiotherapy combined with CMNa group are superior to the radiotherapy alone group. However,the occurrence rates of adverse reactions in the two groups have no obvious differences.